glucocorticoid-induced TNF receptor | Tumour necrosis factor (TNF) receptor family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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glucocorticoid-induced TNF receptor

  Target has curated data in GtoImmuPdb

Target id: 1890

Nomenclature: glucocorticoid-induced TNF receptor

Abbreviated Name: GITR

Systematic Nomenclature: TNFRSF18

Family: Tumour necrosis factor (TNF) receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 241 01p36.33 TNFRSF18 TNF receptor superfamily member 18
Mouse 1 228 Tnfrsf18 tumor necrosis factor receptor superfamily, member 18
Rat - - Tnfrsf18 TNF receptor superfamily member 18
Previous and Unofficial Names
activation-inducible TNFR family receptor | AITR | Glucocorticoid-induced TNFR-related protein | tumor necrosis factor receptor superfamily, member 18 | CD357 | tumor necrosis factor receptor superfamily
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Natural/Endogenous Ligands
TL6 {Sp: Human}
Adaptor proteins (Human)
TRAF1, TRAF2, TRAF3, SIVA
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Parameter Reference
TL6 {Sp: Human} Hs - - -
Immunopharmacology Comments
GITR appears to act as a co-stimulatory immune checkpoint molecule. T cell activation induces GITR expression. GITR inhibits the suppressive activity of Treg cells and promotes survival of Teff cells.
Immuno Process Associations
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0045589 regulation of regulatory T cell differentiation TAS
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0045589 regulation of regulatory T cell differentiation TAS
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0002687 positive regulation of leukocyte migration IMP
Immuno Process:  Immune system development
GO Annotations:  Associated to 1 GO processes
GO:0045589 regulation of regulatory T cell differentiation TAS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 2 GO processes
GO:0002687 positive regulation of leukocyte migration IMP
GO:0045589 regulation of regulatory T cell differentiation TAS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 2 GO processes
GO:0005031 tumor necrosis factor-activated receptor activity TAS
GO:0033209 tumor necrosis factor-mediated signaling pathway TAS
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes
GO:0002687 positive regulation of leukocyte migration IMP

Contributors

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How to cite this page

David MacEwan.
Tumour necrosis factor (TNF) receptor family: glucocorticoid-induced TNF receptor. Last modified on 22/03/2017. Accessed on 20/05/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1890.