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Target has curated data in GtoImmuPdb
Target id: 1890
Nomenclature: glucocorticoid-induced TNF receptor
Abbreviated Name: GITR
Systematic Nomenclature: TNFRSF18
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 1 | 241 | 1p36.33 | TNFRSF18 | TNF receptor superfamily member 18 | |
Mouse | 1 | 228 | 4 E2 | Tnfrsf18 | tumor necrosis factor receptor superfamily, member 18 | |
Rat | - | - | Tnfrsf18 | TNF receptor superfamily member 18 |
Database Links | |
Alphafold | Q9Y5U5 (Hs), O35714 (Mm) |
ChEMBL Target | CHEMBL3712995 (Hs) |
Ensembl Gene | ENSG00000186891 (Hs), ENSMUSG00000041954 (Mm), ENSRNOG00000022012 (Rn) |
Entrez Gene | 8784 (Hs), 21936 (Mm), 500598 (Rn) |
Human Protein Atlas | ENSG00000186891 (Hs) |
KEGG Gene | hsa:8784 (Hs), mmu:21936 (Mm), rno:500598 (Rn) |
OMIM | 603905 (Hs) |
Pharos | Q9Y5U5 (Hs) |
UniProtKB | Q9Y5U5 (Hs), O35714 (Mm) |
Wikipedia | TNFRSF18 (Hs) |
Natural/Endogenous Ligands |
TL6 {Sp: Human} |
Adaptor proteins (Human) |
TRAF1, TRAF2, TRAF3, SIVA |
Other Binding Ligands | |||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Immunopharmacology Comments |
GITR appears to act as a co-stimulatory immune checkpoint molecule. T cell activation induces GITR expression. GITR inhibits the suppressive activity of Treg cells and promotes survival of Teff cells. |
Immuno Process Associations | ||
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