receptor activator of NF-kappa B | Tumour necrosis factor (TNF) receptor family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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receptor activator of NF-kappa B

  Target has curated data in GtoImmuPdb

Target id: 1881

Nomenclature: receptor activator of NF-kappa B

Abbreviated Name: RANK

Systematic Nomenclature: TNFRSF11A

Family: Tumour necrosis factor (TNF) receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 616 18q21.33 TNFRSF11A TNF receptor superfamily member 11a
Mouse 1 625 Tnfrsf11a tumor necrosis factor receptor superfamily
Rat - - Tnfrsf11a TNF receptor superfamily member 11A
Previous and Unofficial Names
CD265 | ODFR | osteoclast differentiation factor receptor | TRANCE-R | tumor necrosis factor receptor superfamily, member 11a, NFKB activator | tumor necrosis factor receptor superfamily, member 11a | tumor necrosis factor receptor superfamily member 11a | tumor necrosis factor receptor superfamily
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Natural/Endogenous Ligands
RANK ligand {Sp: Human}
Adaptor proteins (Human)
TRAF1, TRAF2, TRAF3, TRAF5, TRAF6
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Parameter Reference
RANK ligand {Sp: Human} Hs - - -
Immunopharmacology Comments
RANK is the receptor for RANK-ligand (RANKL). It is associated with immune cell function and lymph node development, in addition to bone remodeling and repair, thermal regulation, and mammary gland development. Signals to NF-κB and JNK via TRAF adaptor proteins.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0002548 monocyte chemotaxis NAS
GO:0006954 inflammatory response IBA
GO:0071812 positive regulation of fever generation by positive regulation of prostaglandin secretion ISS
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0002250 adaptive immune response IMP
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0002250 adaptive immune response IMP
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0071812 positive regulation of fever generation by positive regulation of prostaglandin secretion ISS
Immuno Process:  Immune system development
GO Annotations:  Associated to 3 GO processes
GO:0030316 osteoclast differentiation IMP
click arrow to show/hide IEA associations
GO:0048535 lymph node development IEA
GO:0072674 multinuclear osteoclast differentiation IEA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 7 GO processes
GO:0005031 tumor necrosis factor-activated receptor activity ISS
GO:0033209 tumor necrosis factor-mediated signaling pathway ISS
GO:0034097 response to cytokine IMP
GO:0034612 response to tumor necrosis factor ISS
GO:0070555 response to interleukin-1 ISS
GO:0071847 TNFSF11-mediated signaling pathway IMP
GO:0071848 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling IMP
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes
GO:0002548 monocyte chemotaxis NAS

Contributors

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How to cite this page

David MacEwan.
Tumour necrosis factor (TNF) receptor family: receptor activator of NF-kappa B. Last modified on 22/03/2017. Accessed on 26/04/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1881.