receptor activator of NF-kappa B | Tumour necrosis factor (TNF) receptor family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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receptor activator of NF-kappa B

  Target has curated data in GtoImmuPdb

Target id: 1881

Nomenclature: receptor activator of NF-kappa B

Abbreviated Name: RANK

Systematic Nomenclature: TNFRSF11A

Family: Tumour necrosis factor (TNF) receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 616 18q21.33 TNFRSF11A TNF receptor superfamily member 11a
Mouse 1 625 Tnfrsf11a tumor necrosis factor receptor superfamily
Rat - - Tnfrsf11a TNF receptor superfamily member 11A
Previous and Unofficial Names
CD265 | ODFR | osteoclast differentiation factor receptor | TRANCE-R | tumor necrosis factor receptor superfamily, member 11a, NFKB activator | tumor necrosis factor receptor superfamily, member 11a | tumor necrosis factor receptor superfamily member 11a | tumor necrosis factor receptor superfamily
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Adaptor proteins (Human)
TRAF1, TRAF2, TRAF3, TRAF5, TRAF6
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Parameter Reference
RANK ligand {Sp: Human} Hs - - -
Immunopharmacology Comments
RANK is the receptor for RANK-ligand (RANKL). It is associated with immune cell function and lymph node development, in addition to bone remodeling and repair, thermal regulation, and mammary gland development. Signals to NF-κB and JNK via TRAF adaptor proteins.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0002548 monocyte chemotaxis NAS
GO:0006954 inflammatory response IBA
GO:0071812 positive regulation of fever generation by positive regulation of prostaglandin secretion ISS
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0002250 adaptive immune response IMP
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0002250 adaptive immune response IMP
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0071812 positive regulation of fever generation by positive regulation of prostaglandin secretion ISS
Immuno Process:  Immune system development
GO Annotations:  Associated to 3 GO processes
GO:0030316 osteoclast differentiation IMP
click arrow to show/hide IEA associations
GO:0048535 lymph node development IEA
GO:0072674 multinuclear osteoclast differentiation IEA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 7 GO processes
GO:0005031 tumor necrosis factor-activated receptor activity ISS
GO:0033209 tumor necrosis factor-mediated signaling pathway ISS
GO:0034097 response to cytokine IMP
GO:0034612 response to tumor necrosis factor ISS
GO:0070555 response to interleukin-1 ISS
GO:0071847 TNFSF11-mediated signaling pathway IMP
GO:0071848 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling IMP
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes
GO:0002548 monocyte chemotaxis NAS

Contributors

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How to cite this page

David MacEwan.
Tumour necrosis factor (TNF) receptor family: receptor activator of NF-kappa B. Last modified on 22/03/2017. Accessed on 16/02/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1881.