Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	616	18q21.33	TNFRSF11A	TNF receptor superfamily member 11a
Mouse	1	625	1 E2.1	Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Rat	-	-		Tnfrsf11a	TNF receptor superfamily member 11A

Previous and Unofficial Names

CD265 | ODFR | osteoclast differentiation factor receptor | TRANCE-R | tumor necrosis factor receptor superfamily, member 11a, NFKB activator | tumor necrosis factor receptor superfamily, member 11a | tumor necrosis factor receptor superfamily member 11a | tumor necrosis factor receptor superfamily

Database Links
Alphafold	Q9Y6Q6 (Hs), O35305 (Mm)
Ensembl Gene	ENSG00000141655 (Hs), ENSMUSG00000026321 (Mm), ENSRNOG00000015615 (Rn)
Entrez Gene	8792 (Hs), 21934 (Mm), 498206 (Rn)
Human Protein Atlas	ENSG00000141655 (Hs)
KEGG Gene	hsa:8792 (Hs), mmu:21934 (Mm), rno:498206 (Rn)
OMIM	603499 (Hs)
Pharos	Q9Y6Q6 (Hs)
UniProtKB	Q9Y6Q6 (Hs), O35305 (Mm)
Wikipedia	TNFRSF11A (Hs)

Natural/Endogenous Ligands
RANK ligand {Sp: Human}

Adaptor proteins (Human)

TRAF1, TRAF2, TRAF3, TRAF5, TRAF6

Other Binding Ligands
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Reference RANK ligand {Sp: Human} Hs - - - ⤷

Immunopharmacology Comments

RANK is the receptor for RANK-ligand (RANKL). It is associated with immune cell function and lymph node development, in addition to bone remodeling and repair, thermal regulation, and mammary gland development. Signals to NF-κB and JNK via TRAF adaptor proteins.

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  T cell (activation)

Immuno Process:  B cell (activation)

Immuno Process:  Immune regulation

Immuno Process:  Immune system development

Immuno Process:  Cytokine production & signalling

Immuno Process:  Chemotaxis & migration