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NLRX1

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 1766

Nomenclature: NLRX1

Family: NOD-like receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 975 11q23.3 NLRX1 NLR family member X1
Mouse - 975 9 A5.2 Nlrx1 NLR family member X1
Rat - 973 8q22 Nlrx1 NLR family member X1
Previous and Unofficial Names Click here for help
CLR11.3 | NOD9 | NOD-like receptor X1 | NLR family member X1 | DLNB26 | NOD26 | NOD5
Database Links Click here for help
Alphafold
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Immunopharmacology Comments
NLRX1 is an intracellular pattern recognition receptor that plays a role in host immunity to certain bacterial infections.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 4 GO processes
GO:0032480 negative regulation of type I interferon production TAS
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GO:0032688 negative regulation of interferon-beta production IEA
GO:0032715 negative regulation of interleukin-6 production IEA
GO:0039536 negative regulation of RIG-I signaling pathway IEA
Immuno Process:  Inflammation
GO Annotations:  Associated to 4 GO processes, IEA only
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GO:0039536 negative regulation of RIG-I signaling pathway IEA
GO:0045087 innate immune response IEA
GO:0045824 negative regulation of innate immune response IEA
GO:0050728 negative regulation of inflammatory response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 3 GO processes, IEA only
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GO:0039536 negative regulation of RIG-I signaling pathway IEA
GO:0045824 negative regulation of innate immune response IEA
GO:0050728 negative regulation of inflammatory response IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0039536 negative regulation of RIG-I signaling pathway IEA
Physiological Functions Comments
Involved in negative regulation of inflammatory signalling.

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