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nucleotide binding oligomerization domain containing 1

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 1762

Nomenclature: nucleotide binding oligomerization domain containing 1

Abbreviated Name: NOD1

Family: NOD-like receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 953 7p14.3 NOD1 nucleotide binding oligomerization domain containing 1
Mouse - 953 6 B3 Nod1 nucleotide-binding oligomerization domain containing 1
Rat - - 4q24 Nod1 nucleotide-binding oligomerization domain containing 1
Previous and Unofficial Names Click here for help
CARD4 | caspase recruitment domain family, member 4 | CLR7.1 | NLRC1 | NLR family, CARD domain containing 1 | nucleotide-binding oligomerization domain containing 1 | nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 1 (NLRC1)
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
ML130 Small molecule or natural product Primary target of this compound Click here for species-specific activity table Immunopharmacology Ligand Hs Inhibition 6.3 pIC50 1
pIC50 6.3 (IC50 5.6x10-7 M) [1]
Immunopharmacology Comments
NOD1 is an intracellular pattern recognition receptor that initiates an immune response to bacterial molecules containing a D-glutamyl-meso-diaminopimelic acid (iE-DAP) moiety.

Mutations in NOD proteins are implicated in various inflammatory diseases associated with aberrant NF-κB activity; NF-κB being a major component of the signaling pathways involved in apoptosis, inflammation, and the immune response.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0006954 inflammatory response TAS
GO:0038187 pattern recognition receptor activity IDA
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GO:0045087 innate immune response IEA
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 1 GO processes
GO:0002606 positive regulation of dendritic cell antigen processing and presentation ISS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0002606 positive regulation of dendritic cell antigen processing and presentation ISS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 5 GO processes
GO:0032637 interleukin-8 production IDA
GO:0070498 interleukin-1-mediated signaling pathway TAS
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GO:0032731 positive regulation of interleukin-1 beta production IEA
GO:0032755 positive regulation of interleukin-6 production IEA
GO:0032760 positive regulation of tumor necrosis factor production IEA
Immuno Process:  Cellular signalling
Immuno Disease Associations
Disease Name:  Behcet syndrome
Disease Synonyms:  no synonynms
Comment:  Genetic variations in NOD1 are associated with Behcet's disease in a Chinese Han population, and confer disease susceptibility.
Disease X-refs:  Disease Ontology: DOID:13241
OMIM: 109650
Orphanet: ORPHA117
References:  2
Physiological Functions Comments
Pro-inflammatory, involved in autophagy.

References

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1. Khan PM, Correa RG, Divlianska DB, Peddibhotla S, Sessions EH, Magnuson G, Brown B, Suyama E, Yuan H, Mangravita-Novo A et al.. (2011) Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation. ACS Med Chem Lett, 2 (10): 780-785. [PMID:22003428]

2. Li L, Yu H, Jiang Y, Deng B, Bai L, Kijlstra A, Yang P. (2016) Genetic Variations of NLR family genes in Behcet's Disease. Sci Rep, 6: 20098. [PMID:26833430]

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