Top ▲

TLR6

Click here for help

Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 1756

Nomenclature: TLR6

Family: Toll-like receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 796 4p14 TLR6 toll like receptor 6
Mouse 1 795 5 33.54 cM Tlr6 toll-like receptor 6
Rat - - 14p11 Tlr6 toll-like receptor 6
Previous and Unofficial Names Click here for help
CD286 | toll-like receptor 6
Database Links Click here for help
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Immunopharmacology Comments
TLR6 forms heterodimers with TLR2 to detect a wide range of bacterial lipopeptides (LP) from bacterial cell membranes, and effect an immune response [1]. TLR2/6 dimers perferentially detect diacylated LP [2]. Pam2Cys-SKKKK is a synthetic LP which induces signalling through TLR2/TLR6 heteromers. Activation of TLR2-TLR6 heteromers by LP promotes formation of a functional signalling complex that includes MyD88 and IL-1R-associated kinase (IRAK) proteins, that ultimately initiates NF-κB-mediated cytokine production.
Cell Type Associations
Immuno Cell Type:  Dendritic cells
Cell Ontology Term:   dendritic cell (CL:0000451)
Comment:  NB monocyte-derived immature DCs.
References:  2
Immuno Cell Type:  Granulocytes
Cell Ontology Term:   neutrophil (CL:0000775)
References:  2
Immuno Cell Type:  Macrophages & monocytes
Cell Ontology Term:   monocyte (CL:0000576)
References:  2
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 6 GO processes
GO:0006954 inflammatory response IBA
GO:0043032 positive regulation of macrophage activation ISS
GO:0050729 positive regulation of inflammatory response IGI
GO:1900017 positive regulation of cytokine production involved in inflammatory response ISS
click arrow to show/hide IEA associations
GO:0001774 microglial cell activation IEA
GO:0045087 innate immune response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 3 GO processes
GO:0043032 positive regulation of macrophage activation ISS
GO:0050729 positive regulation of inflammatory response IGI
GO:1900017 positive regulation of cytokine production involved in inflammatory response ISS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 4 GO processes
GO:0032611 interleukin-1 beta production ISS
GO:0032717 negative regulation of interleukin-8 production IGI
GO:0032755 positive regulation of interleukin-6 production ISS
GO:1900017 positive regulation of cytokine production involved in inflammatory response ISS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 2 GO processes
GO:0043032 positive regulation of macrophage activation ISS
click arrow to show/hide IEA associations
GO:0001774 microglial cell activation IEA
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Aspergillosis
Disease Ontology: DOID:13564
Disease:  Asthma, susceptibility to
Disease Ontology: DOID:2841
OMIM: 600807
Disease:  Prostate cancer
Disease Ontology: DOID:10283
OMIM: 176807

References

Show »

1. Farhat K, Riekenberg S, Heine H, Debarry J, Lang R, Mages J, Buwitt-Beckmann U, Röschmann K, Jung G, Wiesmüller KH et al.. (2008) Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling. J Leukoc Biol, 83 (3): 692-701. [PMID:18056480]

2. Nakao Y, Funami K, Kikkawa S, Taniguchi M, Nishiguchi M, Fukumori Y, Seya T, Matsumoto M. (2005) Surface-expressed TLR6 participates in the recognition of diacylated lipopeptide and peptidoglycan in human cells. J Immunol, 174 (3): 1566-73. [PMID:15661917]

Contributors

Show »

How to cite this page