TLR6

Immunopharmacology Ligand Target has curated data in GtoImmuPdb

Target id: 1756

Nomenclature: TLR6

Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	796	4p14	TLR6	toll like receptor 6
Mouse	1	795	5 33.54 cM	Tlr6	toll-like receptor 6
Rat	-	-	14p11	Tlr6	toll-like receptor 6

Previous and Unofficial Names
CD286 \| toll-like receptor 6

Database Links
Alphafold	Q9Y2C9 (Hs), Q9EPW9 (Mm)
CATH/Gene3D	3.40.50.10140, 3.80.10.10
ChEMBL Target	CHEMBL3259477 (Hs), CHEMBL2146341 (Mm)
Ensembl Gene	ENSG00000174130 (Hs), ENSMUSG00000051498 (Mm), ENSRNOG00000002161 (Rn)
Entrez Gene	10333 (Hs), 21899 (Mm), 305353 (Rn)
Human Protein Atlas	ENSG00000174130 (Hs)
KEGG Gene	hsa:10333 (Hs), mmu:21899 (Mm), rno:305353 (Rn)
OMIM	605403 (Hs)
Pharos	Q9Y2C9 (Hs)
UniProtKB	Q9Y2C9 (Hs), Q9EPW9 (Mm)
Wikipedia	TLR6 (Hs)

Immunopharmacology Comments
TLR6 forms heterodimers with TLR2 to detect a wide range of bacterial lipopeptides (LP) from bacterial cell membranes, and effect an immune response [1]. TLR2/6 dimers perferentially detect diacylated LP [2]. Pam2Cys-SKKKK is a synthetic LP which induces signalling through TLR2/TLR6 heteromers. Activation of TLR2-TLR6 heteromers by LP promotes formation of a functional signalling complex that includes MyD88 and IL-1R-associated kinase (IRAK) proteins, that ultimately initiates NF-κB-mediated cytokine production.

Immunopharmacology Comments

TLR6 forms heterodimers with TLR2 to detect a wide range of bacterial lipopeptides (LP) from bacterial cell membranes, and effect an immune response [1]. TLR2/6 dimers perferentially detect diacylated LP [2]. Pam2Cys-SKKKK is a synthetic LP which induces signalling through TLR2/TLR6 heteromers. Activation of TLR2-TLR6 heteromers by LP promotes formation of a functional signalling complex that includes MyD88 and IL-1R-associated kinase (IRAK) proteins, that ultimately initiates NF-κB-mediated cytokine production.

Cell Type Associations

Immuno Cell Type:	Dendritic cells
Cell Ontology Term:	dendritic cell (CL:0000451)
Comment:	NB monocyte-derived immature DCs.
References:	2

Immuno Cell Type:	Granulocytes
Cell Ontology Term:	neutrophil (CL:0000775)
References:	2

Immuno Cell Type:	Macrophages & monocytes
Cell Ontology Term:	monocyte (CL:0000576)
References:	2

Immuno Process Associations

Immuno Process:

Inflammation

Immuno Process:

Immune regulation

Immuno Process:

Cytokine production & signalling

Immuno Process:

Cellular signalling

Clinically-Relevant Mutations and Pathophysiology

Disease:

Aspergillosis

Disease Ontology:

DOID:13564

Disease:

Asthma, susceptibility to

Disease Ontology:	DOID:2841
OMIM:	600807

Disease:

Prostate cancer

Disease Ontology:	DOID:10283
OMIM:	176807

References

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1. Farhat K, Riekenberg S, Heine H, Debarry J, Lang R, Mages J, Buwitt-Beckmann U, Röschmann K, Jung G, Wiesmüller KH et al.. (2008) Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling. J Leukoc Biol, 83 (3): 692-701. [PMID:18056480]

2. Nakao Y, Funami K, Kikkawa S, Taniguchi M, Nishiguchi M, Fukumori Y, Seya T, Matsumoto M. (2005) Surface-expressed TLR6 participates in the recognition of diacylated lipopeptide and peptidoglycan in human cells. J Immunol, 174 (3): 1566-73. [PMID:15661917]

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