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Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 1 | 858 | 1q41 | TLR5 | toll like receptor 5 | |
Mouse | 1 | 859 | 1 86.12 cM | Tlr5 | toll-like receptor 5 | |
Rat | - | - | 13q26 | Tlr5 | toll-like receptor 5 |
Previous and Unofficial Names |
SLEB1 | TIL3 | Toll/interleukin-1 receptor-like protein 3 | toll-like receptor 5 | MELIOS | RP11-239E10.1 |
Database Links | |
Alphafold | O60602 (Hs), Q9JLF7 (Mm) |
CATH/Gene3D | 3.40.50.10140, 3.80.10.10 |
ChEMBL Target | CHEMBL2176839 (Hs) |
Ensembl Gene | ENSG00000187554 (Hs), ENSMUSG00000079164 (Mm), ENSRNOG00000022067 (Rn) |
Entrez Gene | 7100 (Hs), 53791 (Mm), 289337 (Rn) |
Human Protein Atlas | ENSG00000187554 (Hs) |
KEGG Gene | hsa:7100 (Hs), mmu:53791 (Mm), rno:289337 (Rn) |
OMIM | 603031 (Hs) |
Pharos | O60602 (Hs) |
UniProtKB | O60602 (Hs), Q9JLF7 (Mm) |
Wikipedia | TLR5 (Hs) |
Immunopharmacology Comments |
TLR5 induces a pro-inflammatory response upon detection of extracellular bacterial flagellin from invading mobile bacteria [1]. In contrast, cytosolic flagellin in macrophages is recognised by NOD-like receptor NLRC4 (Ipaf). |
Clinically-Relevant Mutations and Pathophysiology | ||||||||||||
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