Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	858	1q41	TLR5	toll like receptor 5
Mouse	1	859	1 86.12 cM	Tlr5	toll-like receptor 5
Rat	-	-	13q26	Tlr5	toll-like receptor 5

Previous and Unofficial Names

SLEB1 | TIL3 | Toll/interleukin-1 receptor-like protein 3 | toll-like receptor 5 | MELIOS | RP11-239E10.1

Database Links
Alphafold	O60602 (Hs), Q9JLF7 (Mm)
CATH/Gene3D	3.40.50.10140, 3.80.10.10
ChEMBL Target	CHEMBL2176839 (Hs)
Ensembl Gene	ENSG00000187554 (Hs), ENSMUSG00000079164 (Mm), ENSRNOG00000022067 (Rn)
Entrez Gene	7100 (Hs), 53791 (Mm), 289337 (Rn)
Human Protein Atlas	ENSG00000187554 (Hs)
KEGG Gene	hsa:7100 (Hs), mmu:53791 (Mm), rno:289337 (Rn)
OMIM	603031 (Hs)
Pharos	O60602 (Hs)
UniProtKB	O60602 (Hs), Q9JLF7 (Mm)
Wikipedia	TLR5 (Hs)

Immunopharmacology Comments

TLR5 induces a pro-inflammatory response upon detection of extracellular bacterial flagellin from invading mobile bacteria [1]. In contrast, cytosolic flagellin in macrophages is recognised by NOD-like receptor NLRC4 (Ipaf).

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  Immune regulation

Immuno Process:  Cytokine production & signalling

Immuno Process:  Cellular signalling

Clinically-Relevant Mutations and Pathophysiology
Disease:  Asthma, susceptibility to Disease Ontology: DOID:2841 OMIM: 600807
Disease:  Gastric cancer Synonyms: Stomach cancer Disease Ontology: DOID:10534 OMIM: 613659
Disease:  Legionnaire disease, susceptibility to Synonyms: Legionnaires' disease [Disease Ontology: DOID:10457] Disease Ontology: DOID:10457 OMIM: 608556
Disease:  Melioidosis, susceptibility to Disease Ontology: DOID:5052 OMIM: 615557
Disease:  Metabolic syndrome Synonyms: Metabolic syndrome X [Disease Ontology: DOID:14221] Disease Ontology: DOID:14221
Disease:  Pneumonia Disease Ontology: DOID:552
Disease:  Systemic lupus erythematosus, susceptibility to, 1; SLEB1 Synonyms: Systemic lupus erythematosus [Disease Ontology: DOID:9074] Disease Ontology: DOID:9074 OMIM: 601744