Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	838	1q32.3-q42	TLR5	toll like receptor 5
Mouse	-	833	1 86.12 cM	Tlr5	toll-like receptor 5
Rat	-	-	13q26	Tlr5	toll-like receptor 5

Previous and Unofficial Names

SLEB1 | TIL3 | Toll/interleukin-1 receptor-like protein 3 | toll-like receptor 5 | MELIOS | RP11-239E10.1

Database Links
CATH/Gene3D	3.40.50.10140, 3.80.10.10
ChEMBL Target	CHEMBL2176839 (Hs)
Ensembl Gene	ENSG00000187554 (Hs), ENSMUSG00000079164 (Mm), ENSRNOG00000022067 (Rn)
Entrez Gene	7100 (Hs), 53791 (Mm), 289337 (Rn)
Human Protein Atlas	ENSG00000187554 (Hs)
KEGG Gene	hsa:7100 (Hs), mmu:53791 (Mm), rno:289337 (Rn)
OMIM	603031 (Hs)
UniProtKB	O60602 (Hs), Q9JLF7 (Mm)
Wikipedia	TLR5 (Hs)

Immunopharmacology Comments

TLR5 induces a pro-inflammatory response upon detection of extracellular bacterial flagellin from invading mobile bacteria [1]. In contrast, cytosolic flagellin in macrophages is recognised by NOD-like receptor NLRC4 (Ipaf).

Immuno Process Associations

Immuno Process:  Inflammation GO Annotations:  Associated to 5 GO processes GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS GO:0034123 positive regulation of toll-like receptor signaling pathway IDA GO:0034146 toll-like receptor 5 signaling pathway TAS click arrow to show/hide IEA associations GO:0006954 inflammatory response IEA GO:0045087 innate immune response IEA

Immuno Process:  Immune regulation GO Annotations:  Associated to 3 GO processes GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS GO:0034123 positive regulation of toll-like receptor signaling pathway IDA GO:0034146 toll-like receptor 5 signaling pathway TAS

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 2 GO processes GO:0032757 positive regulation of interleukin-8 production IDA click arrow to show/hide IEA associations GO:0050707 regulation of cytokine secretion IEA

Immuno Process:  Cellular signalling GO Annotations:  Associated to 3 GO processes GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS GO:0034123 positive regulation of toll-like receptor signaling pathway IDA GO:0034146 toll-like receptor 5 signaling pathway TAS

Clinically-Relevant Mutations and Pathophysiology
Disease:  Asthma, susceptibility to Disease Ontology: DOID:2841 OMIM: 600807
Disease:  Gastric cancer Synonyms: Stomach cancer Disease Ontology: DOID:10534 OMIM: 613659
Disease:  Legionnaire disease, susceptibility to Synonyms: Legionnaires' disease [Disease Ontology: DOID:10457] Disease Ontology: DOID:10457 OMIM: 608556
Disease:  Melioidosis, susceptibility to Disease Ontology: DOID:5052 OMIM: 615557
Disease:  Metabolic syndrome Synonyms: Metabolic syndrome X [Disease Ontology: DOID:14221] Disease Ontology: DOID:14221
Disease:  Pneumonia Disease Ontology: DOID:552
Disease:  Systemic lupus erythematosus, susceptibility to, 1; SLEB1 Synonyms: Systemic lupus erythematosus [Disease Ontology: DOID:9074] Disease Ontology: DOID:9074 OMIM: 601744