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Interleukin 17 receptor A

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 1738

Nomenclature: Interleukin 17 receptor A

Family: IL-17 receptor family

Quaternary Structure: Complexes
Interleukin-17 receptor
Interleukin-25 receptor
Interleukin-17C receptor
Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 866 22q11.1 IL17RA interleukin 17 receptor A
Mouse 1 864 6 56.95 cM Il17ra interleukin 17 receptor A
Rat - - Il17ra interleukin 17 receptor A
Previous and Unofficial Names Click here for help
CD217 | VDw217 | Interleukin-17 α receptor
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia

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Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
brodalumab Peptide Approved drug Primary target of this compound Immunopharmacology Ligand Hs Binding 9.2 pKd 1
pKd 9.2 (Kd 6.9x10-10 M) [1]
Immunopharmacology Comments
This protein is a common subunit shared by the heterodimeric receptors for interleukins 17 (A, B , C and F) and 25.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 9 GO processes
GO:0030368 interleukin-17 receptor activity IBA
GO:0032747 positive regulation of interleukin-23 production IDA
GO:0032755 positive regulation of interleukin-6 production IMP
GO:0071345 cellular response to cytokine stimulus ISO
GO:0097400 interleukin-17-mediated signaling pathway TAS
GO:2000340 positive regulation of chemokine (C-X-C motif) ligand 1 production IMP
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GO:0032736 positive regulation of interleukin-13 production IEA
GO:0032754 positive regulation of interleukin-5 production IEA
GO:1900017 positive regulation of cytokine production involved in inflammatory response IEA
Immuno Process:  Inflammation
GO Annotations:  Associated to 5 GO processes, IEA only
GO:0050729 positive regulation of inflammatory response IMP
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GO:0006954 inflammatory response IEA
GO:0045087 innate immune response IEA
GO:0071621 granulocyte chemotaxis IEA
GO:1900017 positive regulation of cytokine production involved in inflammatory response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 2 GO processes, IEA only
GO:0050729 positive regulation of inflammatory response IMP
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GO:1900017 positive regulation of cytokine production involved in inflammatory response IEA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 2 GO processes, IEA only
GO:2000340 positive regulation of chemokine (C-X-C motif) ligand 1 production IMP
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GO:0071621 granulocyte chemotaxis IEA

References

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1. Tocker J, Mehlin C, Lim AC. (2010) Neutralizing determinants of IL-17 Receptor A and antibodies that bind thereto. Patent number: US7767206. Assignee: Amgen Inc.. Priority date: 02/10/2006. Publication date: 03/08/2010.

How to cite this page

IL-17 receptor family: Interleukin 17 receptor A. Last modified on 07/04/2017. Accessed on 13/04/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1738.