Interleukin-18 receptor 1 | Immunoglobulin-like family of IL-1 receptors | IUPHAR Guide to IMMUNOPHARMACOLOGY

Top ▲

Interleukin-18 receptor 1

  Target has curated data in GtoImmuPdb

Target id: 1737

Nomenclature: Interleukin-18 receptor 1

Family: Immunoglobulin-like family of IL-1 receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Quaternary Structure: Complexes
Interleukin-18 receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 541 02q12.1 IL18R1 interleukin 18 receptor 1
Mouse 1 537 Il18r1 interleukin 18 receptor 1
Rat - - Il18r1 interleukin 18 receptor 1
Previous and Unofficial Names
CD218a | Il18ralpha | IL1RRP | interleukin 18 receptor 1
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Immunopharmacology Comments
Interleukin-18 1 protein (IL18R1) is the ligand binding subunit of the functional IL-18 receptor heterodimer.
Immuno Process Associations
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:2000556 positive regulation of T-helper 1 cell cytokine production IDA
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes, IEA only
GO:2000556 positive regulation of T-helper 1 cell cytokine production IDA
click arrow to show/hide IEA associations
GO:0006954 inflammatory response IEA
GO:0045063 T-helper 1 cell differentiation IEA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 2 GO processes, IEA only
GO:2000556 positive regulation of T-helper 1 cell cytokine production IDA
click arrow to show/hide IEA associations
GO:0045063 T-helper 1 cell differentiation IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 2 GO processes, IEA only
GO:2000556 positive regulation of T-helper 1 cell cytokine production IDA
click arrow to show/hide IEA associations
GO:0045063 T-helper 1 cell differentiation IEA
Immuno Process:  Immune system development
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0045063 T-helper 1 cell differentiation IEA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 6 GO processes, IEA only
GO:0032729 positive regulation of interferon-gamma production IDA
GO:0035655 interleukin-18-mediated signaling pathway IDA
GO:0071345 cellular response to cytokine stimulus TAS
GO:2000556 positive regulation of T-helper 1 cell cytokine production IDA
click arrow to show/hide IEA associations
GO:0004908 interleukin-1 receptor activity IEA
GO:0042008 interleukin-18 receptor activity IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 2 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0030101 natural killer cell activation IEA
GO:0045063 T-helper 1 cell differentiation IEA

How to cite this page

Immunoglobulin-like family of IL-1 receptors: Interleukin-18 receptor 1. Last modified on 30/10/2017. Accessed on 20/05/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1737.