Interleukin 23 receptor | IL-12 receptor family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Interleukin 23 receptor

  Target has curated data in GtoImmuPdb

Target id: 1717

Nomenclature: Interleukin 23 receptor

Family: IL-12 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Contents:

Quaternary Structure: Complexes
Interleukin-23 receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 629 01p31.3 IL23R interleukin 23 receptor
Mouse 1 644 Il23r interleukin 23 receptor
Rat - - Il23r interleukin 23 receptor
Database Links
CATH/Gene3D 2.60.40.10
Ensembl Gene ENSG00000162594 (Hs), ENSMUSG00000049093 (Mm), ENSRNOG00000007544 (Rn)
Entrez Gene 149233 (Hs), 209590 (Mm), 689932 (Rn)
Human Protein Atlas ENSG00000162594 (Hs)
KEGG Gene hsa:149233 (Hs), mmu:209590 (Mm), rno:689932 (Rn)
OMIM 607562 (Hs)
UniProtKB Q5VWK5 (Hs), Q8K4B4 (Mm)
Wikipedia IL23R (Hs)
Immunopharmacology Comments
This is one of the subunits of the functional IL-23 receptor heterodimer.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 4 GO processes
GO:0034341 response to interferon-gamma IDA
GO:0043382 positive regulation of memory T cell differentiation ISS
GO:2000330 positive regulation of T-helper 17 cell lineage commitment ISS
click arrow to show/hide IEA associations
GO:0006954 inflammatory response IEA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 8 GO processes
GO:0001916 positive regulation of T cell mediated cytotoxicity ISS
GO:0002827 positive regulation of T-helper 1 type immune response IDA
GO:0042102 positive regulation of T cell proliferation IC
GO:0042104 positive regulation of activated T cell proliferation IC
GO:0043382 positive regulation of memory T cell differentiation ISS
GO:0051135 positive regulation of NK T cell activation IC
GO:2000318 positive regulation of T-helper 17 type immune response ISS
GO:2000330 positive regulation of T-helper 17 cell lineage commitment ISS
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 4 GO processes
GO:0001916 positive regulation of T cell mediated cytotoxicity ISS
GO:0002827 positive regulation of T-helper 1 type immune response IDA
GO:2000318 positive regulation of T-helper 17 type immune response ISS
GO:2000330 positive regulation of T-helper 17 cell lineage commitment ISS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 11 GO processes
GO:0001916 positive regulation of T cell mediated cytotoxicity ISS
GO:0002230 positive regulation of defense response to virus by host IDA
GO:0002827 positive regulation of T-helper 1 type immune response IDA
GO:0032819 positive regulation of natural killer cell proliferation IC
GO:0042102 positive regulation of T cell proliferation IC
GO:0042104 positive regulation of activated T cell proliferation IC
GO:0043382 positive regulation of memory T cell differentiation ISS
GO:0045672 positive regulation of osteoclast differentiation IC
GO:0051135 positive regulation of NK T cell activation IC
GO:2000318 positive regulation of T-helper 17 type immune response ISS
GO:2000330 positive regulation of T-helper 17 cell lineage commitment ISS
Immuno Process:  Immune system development
GO Annotations:  Associated to 3 GO processes
GO:0043382 positive regulation of memory T cell differentiation ISS
GO:0045672 positive regulation of osteoclast differentiation IC
GO:2000330 positive regulation of T-helper 17 cell lineage commitment ISS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 9 GO processes
GO:0019221 cytokine-mediated signaling pathway TAS
GO:0032693 negative regulation of interleukin-10 production IMP
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production IC
GO:0032729 positive regulation of interferon-gamma production IDA
GO:0032735 positive regulation of interleukin-12 production IDA
GO:0032740 positive regulation of interleukin-17 production IC
GO:0034341 response to interferon-gamma IDA
GO:0035722 interleukin-12-mediated signaling pathway TAS
click arrow to show/hide IEA associations
GO:0038155 interleukin-23-mediated signaling pathway IEA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 5 GO processes
GO:0042102 positive regulation of T cell proliferation IC
GO:0042104 positive regulation of activated T cell proliferation IC
GO:0043382 positive regulation of memory T cell differentiation ISS
GO:0051135 positive regulation of NK T cell activation IC
GO:2000330 positive regulation of T-helper 17 cell lineage commitment ISS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 6 GO processes
GO:0032819 positive regulation of natural killer cell proliferation IC
GO:0042102 positive regulation of T cell proliferation IC
GO:0042104 positive regulation of activated T cell proliferation IC
GO:0043382 positive regulation of memory T cell differentiation ISS
GO:0051135 positive regulation of NK T cell activation IC
GO:2000330 positive regulation of T-helper 17 cell lineage commitment ISS

How to cite this page

IL-12 receptor family: Interleukin 23 receptor. Last modified on 22/03/2017. Accessed on 18/02/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1717.