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Interleukin 23 receptor

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 1717

Nomenclature: Interleukin 23 receptor

Family: IL-12 receptor family

Contents:

Quaternary Structure: Complexes
Interleukin-23 receptor
Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 629 1p31.3 IL23R interleukin 23 receptor
Mouse 1 644 6 C1 Il23r interleukin 23 receptor
Rat - - Il23r interleukin 23 receptor
Database Links Click here for help
Alphafold Q5VWK5 (Hs), Q8K4B4 (Mm)
CATH/Gene3D 2.60.40.10
ChEMBL Target CHEMBL4296013 (Hs), CHEMBL4523394 (Mm)
Ensembl Gene ENSG00000162594 (Hs), ENSMUSG00000049093 (Mm), ENSRNOG00000007544 (Rn)
Entrez Gene 149233 (Hs), 209590 (Mm), 689932 (Rn)
Human Protein Atlas ENSG00000162594 (Hs)
KEGG Gene hsa:149233 (Hs), mmu:209590 (Mm), rno:689932 (Rn)
OMIM 607562 (Hs)
Pharos Q5VWK5 (Hs)
UniProtKB Q5VWK5 (Hs), Q8K4B4 (Mm)
Wikipedia IL23R (Hs)
Immunopharmacology Comments
This is one of the subunits of the functional IL-23 receptor heterodimer.
Immuno Process Associations
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 4 GO processes
GO:0001916 positive regulation of T cell mediated cytotoxicity ISS
GO:0002827 positive regulation of T-helper 1 type immune response IDA
GO:2000318 positive regulation of T-helper 17 type immune response ISS
GO:2000330 positive regulation of T-helper 17 cell lineage commitment ISS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 6 GO processes
GO:0032819 positive regulation of natural killer cell proliferation TAS
GO:0042102 positive regulation of T cell proliferation IC
GO:0042104 positive regulation of activated T cell proliferation IC
GO:0043382 positive regulation of memory T cell differentiation ISS
GO:0051135 positive regulation of NK T cell activation TAS
GO:2000330 positive regulation of T-helper 17 cell lineage commitment ISS
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 5 GO processes
GO:0042102 positive regulation of T cell proliferation IC
GO:0042104 positive regulation of activated T cell proliferation IC
GO:0043382 positive regulation of memory T cell differentiation ISS
GO:0051135 positive regulation of NK T cell activation TAS
GO:2000330 positive regulation of T-helper 17 cell lineage commitment ISS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 10 GO processes
GO:0004896 cytokine receptor activity IDA
GO:0004925 prolactin receptor activity IBA
GO:0019221 cytokine-mediated signaling pathway IBA
GO:0032693 negative regulation of interleukin-10 production IMP
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production IC
GO:0032729 positive regulation of type II interferon production IDA
GO:0032735 positive regulation of interleukin-12 production IDA
GO:0032740 positive regulation of interleukin-17 production IC
GO:0034341 response to type II interferon IDA
GO:0038155 interleukin-23-mediated signaling pathway IDA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 10 GO processes
GO:0001916 positive regulation of T cell mediated cytotoxicity ISS
GO:0002827 positive regulation of T-helper 1 type immune response IDA
GO:0032819 positive regulation of natural killer cell proliferation TAS
GO:0042102 positive regulation of T cell proliferation IC
GO:0042104 positive regulation of activated T cell proliferation IC
GO:0043382 positive regulation of memory T cell differentiation ISS
GO:0045672 positive regulation of osteoclast differentiation IC
GO:0051135 positive regulation of NK T cell activation TAS
GO:2000318 positive regulation of T-helper 17 type immune response ISS
GO:2000330 positive regulation of T-helper 17 cell lineage commitment ISS
Immuno Process:  Immune system development
GO Annotations:  Associated to 3 GO processes
GO:0043382 positive regulation of memory T cell differentiation ISS
GO:0045672 positive regulation of osteoclast differentiation IC
GO:2000330 positive regulation of T-helper 17 cell lineage commitment ISS
Immuno Process:  Inflammation
GO Annotations:  Associated to 4 GO processes
GO:0034341 response to type II interferon IDA
GO:0043382 positive regulation of memory T cell differentiation ISS
GO:2000330 positive regulation of T-helper 17 cell lineage commitment ISS
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GO:0006954 inflammatory response IEA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 8 GO processes
GO:0001916 positive regulation of T cell mediated cytotoxicity ISS
GO:0002827 positive regulation of T-helper 1 type immune response IDA
GO:0042102 positive regulation of T cell proliferation IC
GO:0042104 positive regulation of activated T cell proliferation IC
GO:0043382 positive regulation of memory T cell differentiation ISS
GO:0051135 positive regulation of NK T cell activation TAS
GO:2000318 positive regulation of T-helper 17 type immune response ISS
GO:2000330 positive regulation of T-helper 17 cell lineage commitment ISS

How to cite this page

IL-12 receptor family: Interleukin 23 receptor. Last modified on 22/03/2017. Accessed on 06/07/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1717.