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Oncostatin M-specific receptor, β subunit

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 1714

Nomenclature: Oncostatin M-specific receptor, β subunit

Family: IL-6 receptor family

Quaternary Structure: Complexes
Interleukin-31 receptor
Oncostatin-M receptor
Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 979 5p13.1 OSMR oncostatin M receptor
Mouse 1 971 15 3.3 cM Osmr oncostatin M receptor
Rat 1 962 2q16 Osmr oncostatin M receptor
Previous and Unofficial Names Click here for help
oncostatin M receptor | IL-31 receptor subunit beta | IL-31RB | interleukin-31 receptor subunit beta | OSMRB
Database Links Click here for help
Alphafold
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Immunopharmacology Comments
Oncostatin M-specific receptor, β subunit (OSMR) is a component of two functional heterodimeric receptor complexes:
1. OSMR+ interleukin-6 receptor, β subunit (IL6ST) forms the receptor for oncostatin M
2. OSMR+ interleukin-31 receptor, α subunit forms the receptor for IL-31
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0002675 positive regulation of acute inflammatory response IC
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0002675 positive regulation of acute inflammatory response IC
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 6 GO processes
GO:0004896 cytokine receptor activity IBA
GO:0004923 leukemia inhibitory factor receptor activity IBA
GO:0004924 oncostatin-M receptor activity IDA
GO:0019221 cytokine-mediated signaling pathway TAS
GO:0034097 response to cytokine IDA
GO:0038165 oncostatin-M-mediated signaling pathway IMP

How to cite this page

IL-6 receptor family: Oncostatin M-specific receptor, β subunit. Last modified on 07/04/2017. Accessed on 01/12/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1714.