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Cytokine receptor-like factor 2

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 1704

Nomenclature: Cytokine receptor-like factor 2

Family: IL-2 receptor family

Quaternary Structure: Complexes
Thymic stromal lymphopoietin receptor
Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 371 Xp22.3 and Yp11.3 CRLF2 cytokine receptor like factor 2
Mouse 1 359 5 F Crlf2 cytokine receptor-like factor 2
Rat 1 360 14p22 Crlf2 cytokine receptor-like factor 2
Previous and Unofficial Names Click here for help
thymic stromal lymphopoietin protein receptor | Tpte2 | TSLP receptor | Ly114 | CRL2 | transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
Database Links Click here for help
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Immunopharmacology Comments
Cytokine receptor-like factor 2 is the signal transducing subunit of the functional heterodimeric receptor for thymic stromal lymphopoietin (TSLP). Ligand binding is attributed to the interleukin-7 receptor subunit α.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0006954 inflammatory response IMP
GO:0033005 positive regulation of mast cell activation IMP
GO:0035745 T-helper 2 cell cytokine production IDA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0033005 positive regulation of mast cell activation IMP
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 7 GO processes
GO:0004896 cytokine receptor activity IDA
GO:0004923 leukemia inhibitory factor receptor activity IBA
GO:0019221 cytokine-mediated signaling pathway IDA
GO:0032754 positive regulation of interleukin-5 production IMP
GO:0035745 T-helper 2 cell cytokine production IDA
GO:0038111 interleukin-7-mediated signaling pathway TAS
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GO:0038165 oncostatin-M-mediated signaling pathway IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0033005 positive regulation of mast cell activation IMP
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0035745 T-helper 2 cell cytokine production IDA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0035745 T-helper 2 cell cytokine production IDA

How to cite this page

IL-2 receptor family: Cytokine receptor-like factor 2. Last modified on 10/04/2017. Accessed on 03/08/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1704.