Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	813	20p13	ADAM33	ADAM metallopeptidase domain 33
Mouse	1	797	2 63.26 cM	Adam33	a disintegrin and metallopeptidase domain 33
Rat	-	-	3q36	Adam33	ADAM metallopeptidase domain 33

Database Links
Specialist databases
MEROPS	M12.244 (Hs)
Other databases
Alphafold	Q9BZ11 (Hs), Q923W9 (Mm)
BRENDA	3.4.24.-
CATH/Gene3D	3.40.390.10, 4.10.70.10
ChEMBL Target	CHEMBL6121 (Hs)
Ensembl Gene	ENSG00000149451 (Hs), ENSMUSG00000027318 (Mm), ENSRNOG00000021242 (Rn)
Entrez Gene	80332 (Hs), 110751 (Mm), 311425 (Rn)
Human Protein Atlas	ENSG00000149451 (Hs)
KEGG Enzyme	3.4.24.-
KEGG Gene	hsa:80332 (Hs), mmu:110751 (Mm), rno:311425 (Rn)
OMIM	607114 (Hs)
Pharos	Q9BZ11 (Hs)
RefSeq Nucleotide	NM_153202 (Hs), NM_025220 (Hs), NM_033615 (Mm)
RefSeq Protein	NP_079496 (Hs), NP_694882 (Hs), NP_291093 (Mm)
UniProtKB	Q9BZ11 (Hs), Q923W9 (Mm)
Wikipedia	ADAM33 (Hs)

Enzyme Reaction
EC Number: 3.4.24.-

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference IK-862 Hs Inhibition 7.8 pKi 1 ⤷ pKi 7.8 (Ki 1.5x10-8 M) [1] INCB3619 Hs Inhibition 6.0 pIC50 1 ⤷ pIC50 6.0 (IC50 1.026x10-6 M) [1]

Immunopharmacology Comments

ADAM33 is implicated in the pathology of asthma [2].

Immuno Process Associations

Immuno Process:  Cytokine production & signalling

Immuno Disease Associations

Disease Name:  Asthma Disease Synonyms:  no synonynms Comment:  ADAM33 is implicated in the pathology of asthma. Disease X-refs:  Disease Ontology: DOID:2841 OMIM: 600807 References:  2

Clinically-Relevant Mutations and Pathophysiology
Disease:  Asthma, susceptibility to Disease Ontology: DOID:2841 OMIM: 600807