Top ▲

ADAM33

Click here for help

Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 1673

Nomenclature: ADAM33

Family: M12: Astacin/Adamalysin

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 813 20p13 ADAM33 ADAM metallopeptidase domain 33
Mouse 1 797 2 63.26 cM Adam33 a disintegrin and metallopeptidase domain 33
Rat - - 3q36 Adam33 ADAM metallopeptidase domain 33
Database Links Click here for help
Specialist databases
MEROPS M12.244 (Hs)
Other databases
Alphafold
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.24.-

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
IK-862 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 7.8 pKi 1
pKi 7.8 (Ki 1.5x10-8 M) [1]
INCB3619 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 6.0 pIC50 1
pIC50 6.0 (IC50 1.026x10-6 M) [1]
Immunopharmacology Comments
ADAM33 is implicated in the pathology of asthma [2].
Immuno Disease Associations
Disease Name:  Asthma
Disease Synonyms:  no synonynms
Comment:  ADAM33 is implicated in the pathology of asthma.
Disease X-refs:  Disease Ontology: DOID:2841
OMIM: 600807
References:  2
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Asthma, susceptibility to
Disease Ontology: DOID:2841
OMIM: 600807

References

Show »

1. Georgiadis D, Yiotakis A. (2008) Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. Bioorg Med Chem, 16 (19): 8781-94. [PMID:18790648]

2. Van Eerdewegh P, Little RD, Dupuis J, Del Mastro RG, Falls K, Simon J, Torrey D, Pandit S, McKenny J, Braunschweiger K et al.. (2002) Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature, 418 (6896): 426-30. [PMID:12110844]

How to cite this page

M12: Astacin/Adamalysin: ADAM33. Last modified on 16/03/2017. Accessed on 04/12/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1673.