Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	824	10q26.3	ADAM8	ADAM metallopeptidase domain 8
Mouse	1	826	7 F4	Adam8	a disintegrin and metallopeptidase domain 8
Rat	-	-	1q41	Adam8	ADAM metallopeptidase domain 8

Previous and Unofficial Names

Cell surface antigen MS2 | a disintegrin and metalloproteinase domain 8 | ADAM metallopeptidase domain 8 | CD156a

Database Links
Specialist databases
MEROPS	M12.208 (Hs)
Other databases
Alphafold	P78325 (Hs), Q05910 (Mm)
BRENDA	3.4.24.-
CATH/Gene3D	3.40.390.10, 4.10.70.10
ChEMBL Target	CHEMBL5665 (Hs)
Ensembl Gene	ENSG00000151651 (Hs), ENSMUSG00000025473 (Mm), ENSRNOG00000017897 (Rn)
Entrez Gene	101 (Hs), 11501 (Mm), 499285 (Rn)
Human Protein Atlas	ENSG00000151651 (Hs)
KEGG Enzyme	3.4.24.-
KEGG Gene	hsa:101 (Hs), mmu:11501 (Mm), rno:499285 (Rn)
OMIM	602267 (Hs)
Pharos	P78325 (Hs)
RefSeq Nucleotide	NM_001109 (Hs), NM_001164490 (Hs), NM_001164489 (Hs), NM_007403 (Mm)
RefSeq Protein	NP_001157962 (Hs), NP_001157961 (Hs), NP_001100 (Hs), NP_031429 (Mm)
UniProtKB	P78325 (Hs), Q05910 (Mm)
Wikipedia	ADAM8 (Hs)

Enzyme Reaction
EC Number: 3.4.24.-

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference INCB3619 Hs Inhibition 6.0 pIC50 1 ⤷ pIC50 6.0 (IC50 1x10-6 M) [1]

Immunopharmacology Comments

ADAM8 is reported to drive acute allergen-induced airway inflammation in a mouse model, and effect negated by ADAM8-deficiency (antibody-induced or gene knockout) [3]. The potential roles of ADAM8 in inflammation regulation and in experimental asthma are reviewed in [4] and [2] respectively.