Top ▲

ADAM8

Click here for help

Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 1656

Nomenclature: ADAM8

Family: M12: Astacin/Adamalysin

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 824 10q26.3 ADAM8 ADAM metallopeptidase domain 8
Mouse 1 826 7 F4 Adam8 a disintegrin and metallopeptidase domain 8
Rat - - 1q41 Adam8 ADAM metallopeptidase domain 8
Previous and Unofficial Names Click here for help
Cell surface antigen MS2 | a disintegrin and metalloproteinase domain 8 | ADAM metallopeptidase domain 8 | CD156a
Database Links Click here for help
Specialist databases
MEROPS M12.208 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.24.-

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
INCB3619 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 6.0 pIC50 1
pIC50 6.0 (IC50 1x10-6 M) [1]
Immunopharmacology Comments
ADAM8 is reported to drive acute allergen-induced airway inflammation in a mouse model, and effect negated by ADAM8-deficiency (antibody-induced or gene knockout) [3]. The potential roles of ADAM8 in inflammation regulation and in experimental asthma are reviewed in [4] and [2] respectively.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 12 GO processes
GO:0002523 leukocyte migration involved in inflammatory response ISS
GO:0002675 positive regulation of acute inflammatory response ISS
GO:0002693 positive regulation of cellular extravasation IMP
GO:0006954 inflammatory response IDA
GO:0043312 neutrophil degranulation TAS
GO:0045089 positive regulation of innate immune response ISS
GO:0048247 lymphocyte chemotaxis ISS
GO:0050729 positive regulation of inflammatory response IDA
GO:2000391 positive regulation of neutrophil extravasation IDA
GO:2000406 positive regulation of T cell migration IMP
GO:2000415 positive regulation of fibronectin-dependent thymocyte migration ISS
GO:2000418 positive regulation of eosinophil migration ISS
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 2 GO processes
GO:0033089 positive regulation of T cell differentiation in thymus ISS
GO:0070245 positive regulation of thymocyte apoptotic process ISS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 10 GO processes
GO:0002675 positive regulation of acute inflammatory response ISS
GO:0002693 positive regulation of cellular extravasation IMP
GO:0033089 positive regulation of T cell differentiation in thymus ISS
GO:0045089 positive regulation of innate immune response ISS
GO:0045670 regulation of osteoclast differentiation NAS
GO:0050729 positive regulation of inflammatory response IDA
GO:2000391 positive regulation of neutrophil extravasation IDA
GO:2000406 positive regulation of T cell migration IMP
GO:2000415 positive regulation of fibronectin-dependent thymocyte migration ISS
GO:2000418 positive regulation of eosinophil migration ISS
Immuno Process:  Immune system development
GO Annotations:  Associated to 3 GO processes
GO:0033089 positive regulation of T cell differentiation in thymus ISS
GO:0045670 regulation of osteoclast differentiation NAS
GO:0072675 osteoclast fusion TAS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:2000309 positive regulation of tumor necrosis factor (ligand) superfamily member 11 production ISS
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 9 GO processes
GO:0002523 leukocyte migration involved in inflammatory response ISS
GO:0002693 positive regulation of cellular extravasation IMP
GO:0033089 positive regulation of T cell differentiation in thymus ISS
GO:0048247 lymphocyte chemotaxis ISS
GO:2000391 positive regulation of neutrophil extravasation IDA
GO:2000399 negative regulation of thymocyte aggregation NAS
GO:2000406 positive regulation of T cell migration IMP
GO:2000415 positive regulation of fibronectin-dependent thymocyte migration ISS
GO:2000418 positive regulation of eosinophil migration ISS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 2 GO processes
GO:0033089 positive regulation of T cell differentiation in thymus ISS
GO:0043312 neutrophil degranulation TAS

References

Show »

1. Georgiadis D, Yiotakis A. (2008) Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. Bioorg Med Chem, 16 (19): 8781-94. [PMID:18790648]

2. Matsuno O, Miyazaki E, Nureki S, Ueno T, Kumamoto T, Higuchi Y. (2006) Role of ADAM8 in experimental asthma. Immunol Lett, 102 (1): 67-73. [PMID:16154205]

3. Paulissen G, Rocks N, Guéders MM, Bedoret D, Crahay C, Quesada-Calvo F, Hacha J, Bekaert S, Desmet C, Foidart JM et al.. (2011) ADAM-8, a metalloproteinase, drives acute allergen-induced airway inflammation. Eur J Immunol, 41 (2): 380-91. [PMID:21268008]

4. Zarbock A, Rossaint J. (2011) Regulating inflammation: ADAM8--a new player in the game. Eur J Immunol, 41 (12): 3419-22. [PMID:22125009]

How to cite this page

M12: Astacin/Adamalysin: ADAM8. Last modified on 31/01/2017. Accessed on 20/04/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1656.