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Prolylcarboxypeptidase

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Target not currently curated in GtoImmuPdb

Target id: 1584

Nomenclature: Prolylcarboxypeptidase

Family: S28: Lysosomal Pro-Xaa carboxypeptidase

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 496 11q14 PRCP prolylcarboxypeptidase
Mouse - 491 7 E1 Prcp prolylcarboxypeptidase (angiotensinase C)
Rat - 493 1q32 Prcp prolylcarboxypeptidase
Previous and Unofficial Names Click here for help
Angiotensinase C | HUMPCP | lysosomal Pro-X carboxypeptidase | PCP | prolylcarboxypeptidase (angiotensinase C)
Database Links Click here for help
Specialist databases
MEROPS S28.001 (Hs)
Other databases
Alphafold P42785 (Hs), Q7TMR0 (Mm), D4AA31 (Rn)
BRENDA 3.4.16.2
CATH/Gene3D 3.40.50.1820
ChEMBL Target CHEMBL2335 (Hs), CHEMBL1255149 (Mm)
Ensembl Gene ENSG00000137509 (Hs), ENSMUSG00000061119 (Mm), ENSRNOG00000010630 (Rn)
Entrez Gene 5547 (Hs), 72461 (Mm), 293118 (Rn)
Human Protein Atlas ENSG00000137509 (Hs)
KEGG Enzyme 3.4.16.2
KEGG Gene hsa:5547 (Hs), mmu:72461 (Mm), rno:293118 (Rn)
OMIM 176785 (Hs)
Pharos P42785 (Hs)
RefSeq Nucleotide NM_005040 (Hs), NM_199418 (Hs), NM_028243 (Mm), NM_001106281 (Rn)
RefSeq Protein NP_005031 (Hs), NP_955450 (Hs), NP_082519 (Mm), NP_001099751 (Rn)
UniProtKB P42785 (Hs), Q7TMR0 (Mm), D4AA31 (Rn)
Wikipedia PRCP (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.16.2

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 35 [PMID: 24157366] Small molecule or natural product Primary target of this compound Hs Inhibition 10.1 pIC50 1
⤷ pIC50 10.1 (IC50 7.9x10-11 M) [1]

References

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1. Debenham JS, Graham TH, Verras A, Zhang Y, Clements MJ, Kuethe JT, Madsen-Duggan C, Liu W, Bhatt UR, Chen D et al.. (2013) Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors. Bioorg Med Chem Lett, 23 (23): 6228-33. [PMID:24157366]

How to cite this page

S28: Lysosomal Pro-Xaa carboxypeptidase: Prolylcarboxypeptidase. Last modified on 14/07/2015. Accessed on 25/10/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1584.