Gene and Protein Information
class A G protein-coupled receptor
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	338	3q26.2	GPR160	G protein-coupled receptor 160
Mouse	7	336	3 A3	Gpr160	G protein-coupled receptor 160
Rat	7	336	2q24	Gpr160	G protein-coupled receptor 160

Previous and Unofficial Names

GPCR1 | GPCR150

Database Links
Specialist databases
GPCRdb	gp160_human (Hs), gp160_mouse (Mm), gp160_rat (Rn)
Other databases
Alphafold	Q9UJ42 (Hs), Q3U3F9 (Mm), Q66H29 (Rn)
ChEMBL Target	CHEMBL1777664 (Hs)
Ensembl Gene	ENSG00000173890 (Hs), ENSMUSG00000037661 (Mm), ENSRNOG00000009487 (Rn)
Entrez Gene	26996 (Hs), 71862 (Mm), 499588 (Rn)
Human Protein Atlas	ENSG00000173890 (Hs)
KEGG Gene	hsa:26996 (Hs), mmu:71862 (Mm), rno:499588 (Rn)
Pharos	Q9UJ42 (Hs)
RefSeq Nucleotide	NM_014373 (Hs), NM_001134385 (Mm), NM_001025147 (Rn)
RefSeq Protein	NP_055188 (Hs), NP_001127857 (Mm), NP_001020318 (Rn)
UniProtKB	Q9UJ42 (Hs), Q3U3F9 (Mm), Q66H29 (Rn)
Wikipedia	GPR160 (Hs)

Expression Datasets
Show »« Hide Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website] There should be a chart of expression data here, you may need to enable JavaScript!

Functional Assays
miR-125b negatively regulates GPR160 expression in lymphoblastoid cell lines Species:  Human Tissue:  Lymphoblastoid cell line Response measured:  Decreased expression References:  2

Clinically-Relevant Mutations and Pathophysiology
Disease:  Metastatic melanoma Disease Ontology: DOID:4358 Comments:  Receptor overexpression observed in melanoma metastases. References:  4
Disease:  Nasopharyngeal carcinoma OMIM: 607107 Comments:  Increased gene expression seen in nasopharangeal carcinoma identified by combined microarray and FISH analysis. References:  3
Disease:  Prostate cancer Disease Ontology: DOID:10283 OMIM: 176807 Comments:  Gene associated with prostate cancer identified by microarray analysis. References:  1,3

Biologically Significant Variants
Type:  Naturally occurring SNP Species:  Human Amino acid change:  V65I Comment on frequency:  Low frequency (<10% in all tested populations) SNP accession:  rs61745703
Type:  Single nucleotide polymorphism Species:  Human Amino acid change:  Q14E Global MAF (%):  1 Subpopulation MAF (%):  AFR: 4 Minor allele count:  G=0.010/21 Comment on frequency:  Low frequency (<10% in all tested populations) SNP accession:  rs73030619 Validation:  1000 Genomes, Frequency