Synonyms: compound 2c [PMID: 28613862] | Example 1166 [WO2015160641A2]
Compound class:
Synthetic organic
Comment: BMS-1166 is a small molecule that disrupts the PD-1/PD-L1 immune checkpoint interaction. It is the most potent of the [3-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methanol derivatives described in [2], and it is claimed as Example 1166 in Bristol-Myers Squibb's patent WO2015160641A2 [1]. NMR analysis suggests that BMS-1166 promotes the formation of dimeric PD-L1 in solution.
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Classification | |
Compound class | Synthetic organic |
IUPAC Name |
(2R,4R)-1-[[5-chloro-2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]phenyl]methyl]-4-hydroxypyrrolidine-2-carboxylic acid |
Synonyms |
compound 2c [PMID: 28613862] | Example 1166 [WO2015160641A2] |
Database Links | |
GtoPdb PubChem SID | 340590238 |
PubChem CID | 118434635 |
Search Google for chemical match using the InChIKey | QBXVXKRWOVBUDB-GRKNLSHJSA-N |
Search Google for chemicals with the same backbone | QBXVXKRWOVBUDB |
UniChem Compound Search for chemical match using the InChIKey | QBXVXKRWOVBUDB-GRKNLSHJSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | QBXVXKRWOVBUDB-GRKNLSHJSA-N |