ARRY-382   Click here for help

GtoPdb Ligand ID: 9108

Synonyms: ARRY 382 | ARRY382 | c-Fms-IN-12 | PF-07265804 | PF07265804
Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: ARRY-382 is an investigational, orally administered small molecule inhibitor of the receptor tyrosine kinase, CSF1R (Fms).
The chemical structure shown here was reproduced from Offringa et al. (2022) [2].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 10
Hydrogen bond donors 1
Rotatable bonds 10
Topological polar surface area 88.37
Molecular weight 564.68
XLogP 1.23
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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Canonical SMILES CC1=CC=CC(=N1)CN2C3=C(C(=CC=C3)NC(=O)C4=CN=C5C=C(C=CN45)OCCN6CCN(C)CC6)C(=N2)C7CC7
Isomeric SMILES CN1CCN(CCOC2=CC3=NC=C(N3C=C2)C(=O)NC4=CC=CC5=C4C(=NN5CC6=NC(C)=CC=C6)C7CC7)CC1
InChI InChI=1S/C32H36N8O2/c1-22-5-3-6-24(34-22)21-40-27-8-4-7-26(30(27)31(36-40)23-9-10-23)35-32(41)28-20-33-29-19-25(11-12-39(28)29)42-18-17-38-15-13-37(2)14-16-38/h3-8,11-12,19-20,23H,9-10,13-18,21H2,1-2H3,(H,35,41)
InChI Key JUPOTOIJLKDAPF-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
N-[3-cyclopropyl-1-[(6-methylpyridin-2-yl)methyl]indazol-4-yl]-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridine-3-carboxamide
Synonyms Click here for help
ARRY 382 | ARRY382 | c-Fms-IN-12 | PF-07265804 | PF07265804
Database Links Click here for help
BindingDB Ligand 132068
ChEMBL Ligand CHEMBL3644252
GtoPdb PubChem SID 315661193
PubChem CID 67259771
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