GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

margetuximab   Click here for help

GtoPdb Ligand ID: 8686

Synonyms: Margenza® | margetuximab-cmkb | MGAH-22
Approved drug
margetuximab is an approved drug (FDA (2020))
Compound class: Antibody
Comment: Margetuximab is a chimeric monoclonal antibody targeting epidermal growth factor receptor 2 (ERBB2).
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record. Peptide sequence search of patented sequences reveals a 100% match between the heavy chain variable domain of margetuximab and SEQ ID NO: 13 from patent US8802093 B2, and antibody clone ch4D5-FcMT3 [2]. Although the patent describes performing Biacore assays to determine antibody-target (ERBB2) affinity, a KD value is not provided.
Classification Click here for help
Compound class Antibody
Approved drug? Yes. US FDA (2020)
International Nonproprietary Names Click here for help
INN number INN
9799 margetuximab
Synonyms Click here for help
Margenza® | margetuximab-cmkb | MGAH-22
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 473
Other databases
GtoPdb PubChem SID 252166886
Search PubMed clinical trials margetuximab
Search PubMed titles margetuximab
Search PubMed titles/abstracts margetuximab