amlexanox

Ligand id: 7113

Name: amlexanox

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 106.42
Molecular weight 298.1
XLogP 4.41
No. Lipinski's rules broken 0

Molecular properties generated using the CDK
Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1996))
Withdrawn drug? Yes
IUPAC Name
2-amino-5-oxo-7-(propan-2-yl)-5H-chromeno[2,3-b]pyridine-3-carboxylic acid
International Nonproprietary Names
INN number INN
5950 amlexanox
Synonyms
AA-673 | Amlexanox® | Aphthasol® | CHX-3673
Comments
Amlexanox has anti-inflammatory [1], antiallergic and immunomodulatory actions [2]. Proposed to inhibit IKKδ and TBK1, albeit with low potency [5].
Database Links
CAS Registry No. 68302-57-8
ChEMBL Ligand CHEMBL1096
DrugBank Ligand DB01025
GtoPdb PubChem SID 178103690
PubChem CID 2161
RCSB PDB Ligand ANW
Search Google for chemical match using the InChIKey SGRYPYWGNKJSDL-UHFFFAOYSA-N
Search Google for chemicals with the same backbone SGRYPYWGNKJSDL
Search PubMed clinical trials amlexanox
Search PubMed titles amlexanox
Search PubMed titles/abstracts amlexanox
Search UniChem for chemical match using the InChIKey SGRYPYWGNKJSDL-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone SGRYPYWGNKJSDL
Wikipedia Amlexanox

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Tocris
Amlexanox
Cat. No. 4857