alefacept

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alefacept

GtoPdb Ligand ID: 6787

Synonyms: Amevive® | BG 9273 | BG 9712 | BG-9273 | BG-9712 | Lfa3Tip

alefacept is an approved drug (FDA (2003))

Comment: This is a fusion protein of the CD2 ligand (CD58/LFA3, lymphocyte function associated antigen 3) linked to the Fc domain of IgG1. The construct is called LFA3TIP in [2].

Bioactivity Comments
The Miller et al. (1993) article does not provide a calculated IC₅₀ value for LFA3TIP's inhibition of the CD2/LFA-3 interaction [2]. The inhibition is assessed by measuring rosetting of Jurkat/human red blood cells (with an approximate IC₅₀ of 1-5μg/ml of protein from graphical data in Figure 3a), or by measuring inhibition of induced T cell proliferation (with LFA3TIP inhibition at approximately 86%) [2].

Bioactivity Comments

The Miller et al. (1993) article does not provide a calculated IC₅₀ value for LFA3TIP's inhibition of the CD2/LFA-3 interaction [2]. The inhibition is assessed by measuring rosetting of Jurkat/human red blood cells (with an approximate IC₅₀ of 1-5μg/ml of protein from graphical data in Figure 3a), or by measuring inhibition of induced T cell proliferation (with LFA3TIP inhibition at approximately 86%) [2].

Selectivity at other protein targets

Key to terms and symbols

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Target			Sp.	Type	Action	Value	Parameter	Concentration range (M)	Reference
CD2			Hs	Fusion protein	Inhibition	-	-	-	1,3
⤷	[1,3]