Bioactivity Comments

The Miller et al. (1993) article does not provide a calculated IC50 value for LFA3TIP's inhibition of the CD2/LFA-3 interaction [2]. The inhibition is assessed by measuring rosetting of Jurkat/human red blood cells (with an approximate IC50 of 1-5μg/ml of protein from graphical data in Figure 3a), or by measuring inhibition of induced T cell proliferation (with LFA3TIP inhibition at approximately 86%) [2].

Selectivity at other protein targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference CD2 Hs Fusion protein Inhibition - - - 1,3 ⤷ [1,3]