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B and T lymphocyte attenuator   Click here for help

GtoPdb Ligand ID: 4891

Abbreviated name: BTLA
Synonyms: B- and T-lymphocyte attenuator  | B- and T-lymphocyte-associated protein | CD272
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: BTLA is a negative immunomodulator. Interaction of BTLA with TNFRSF14 (HVEM) constitutes an immune checkpoint which inhibits T cell-mediated immune responses. Dysregulated BTLA expression contributes to immunosuppression and progression of some cancers [3-6] by enabling tumour immune evasion. Immunotherapeutics that block the BTLA-HVEM checkpoint offer potential as anti-tumour agents [8-9]. In the setting of inflammatory diseases anti-BTLA antibodies can induce inhibitory signalling and block T cell activation, thus reducing pro-inflammatory cytokine secretion [1].

Several anti-BTLA monoclonals have been progressed to clinical trials. Examples include:
Radanstobart (HFB200603, HiFiBiO; Phase 1 NCT05789069, solid tumours) [2]
Zadoprubart (ANB032, AnaptysBio; Phase 2 NCT05935085, atopic dermatitis; terminated due to insufficient efficacy) [1]
Venanprubart (LY3361237; development for autoimmune conditions terminated at Phase 2)
Tifcemalimab (JS004, icatolimab; Junshi Biosciences for advanced/metaststic solid tumours) [7]
GS-0272 (formerly MB272; Phase 1 NCT06031415 for rheumatoid arthritis was terminated).
Species: Human
Natural/Endogenous Targets
Target
herpes virus entry mediator
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
herpes virus entry mediator Ligand is endogenous in the given species Hs None - - - -
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Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
zadoprubart Peptide Hs Antibody Binding - - -
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