amiloride

Ligand id: 2421

Name: amiloride

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Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 4
Rotatable bonds 2
Topological polar surface area 159.29
Molecular weight 229.05
XLogP -0.47
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1981))
WHO Essential Medicine WHO Model List of Essential Medicines (21st List, 2019). Access PDF version.
IUPAC Name
3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide
International Nonproprietary Names
INN number INN
2352 amiloride
Synonyms
amiloride HCl | Midamor®
Comments
Amiloride is a loop diuretic drug.
Database Links
BindingDB Ligand 16173
CAS Registry No. 2609-46-3
ChEBI CHEBI:2639
ChEMBL Ligand CHEMBL945
DrugBank Ligand DB00594
GtoPdb PubChem SID 135649936
PubChem CID 16231
RCSB PDB Ligand AMR
Search Google for chemical match using the InChIKey XSDQTOBWRPYKKA-UHFFFAOYSA-N
Search Google for chemicals with the same backbone XSDQTOBWRPYKKA
Search PubMed clinical trials amiloride
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Search UniChem for chemical match using the InChIKey XSDQTOBWRPYKKA-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone XSDQTOBWRPYKKA
Wikipedia Amiloride