[Leu31,Pro34]NPY   Click here for help

GtoPdb Ligand ID: 1545

Synonyms: [Leu31,Pro34] neuropeptide Y | [Leu31,Pro34]-NPY
Compound class: Peptide
Comment: Synthetic analogue of the human/rodent NPY natural pepide sequence
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Cox HM, Tough IR. (1995)
Functional characterization of receptors with affinity for PYY, NPY, [Leu31,Pro34]NPY and PP in a human colonic epithelial cell line.
Br J Pharmacol, 116 (6): 2673-8. [PMID:8590988]
2. Gehlert DR, Schober DA, Gackenheimer SL, Beavers L, Gadski R, Lundell I, Larhammar D. (1997)
[125I]Leu31, Pro34-PYY is a high affinity radioligand for rat PP1/Y4 and Y1 receptors: evidence for heterogeneity in pancreatic polypeptide receptors.
Peptides, 18 (3): 397-401. [PMID:9145427]
3. Gerald C, Walker MW, Vaysse PJ, He C, Branchek TA, Weinshank RL. (1995)
Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype.
J Biol Chem, 270 (45): 26758-61. [PMID:7592910]
4. Gregor P, Millham ML, Feng Y, DeCarr LB, McCaleb ML, Cornfield LJ. (1996)
Cloning and characterization of a novel receptor to pancreatic polypeptide, a member of the neuropeptide Y receptor family.
FEBS Lett, 381: 58-62. [PMID:8641440]
5. Krause J, Eva C, Seeburg PH, Sprengel R. (1992)
Neuropeptide Y1 subtype pharmacology of a recombinantly expressed neuropeptide receptor.
Mol Pharmacol, 41 (5): 817-21. [PMID:1316999]
6. Lundell I, Blomqvist AG, Berglund MM, Schober DA, Johnson D, Statnick MA, Gadski RA, Gehlert DR, Larhammar D. (1995)
Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY.
J Biol Chem, 270 (49): 29123-8. [PMID:7493937]
7. Lundell I, Statnick MA, Johnson D, Schober DA, Starbäck P, Gehlert DR, Larhammar D. (1996)
The cloned rat pancreatic polypeptide receptor exhibits profound differences to the orthologous receptor.
Proc Natl Acad Sci USA, 93 (10): 5111-5. [PMID:8643536]
8. Walker MW, Smith KE, Bard J, Vaysse PJ, Gerald C, Daouti S, Weinshank RL, Branchek TA. (1997)
A structure-activity analysis of the cloned rat and human Y4 receptors for pancreatic polypeptide.
Peptides, 18 (4): 609-12. [PMID:9210181]