Synonyms: compound I-C-79 [WO2014089379A1]
Compound class:
Synthetic organic
Comment: We obtained the chemical structure for tuvusertib from the WHO's proposed INN list 127 (21 July 2022). In this document it was described as a serine/ threonine kinase inhibitor and antineoplastic. The structure maps to PubChem CID 90199447, and it is one of the structures that are claimed as ATM and Rad3 related (ATR) kinase inhibitors in patent WO2014089379A1 (Vertex Pharmaceuticals) [1]. We already had Vertex's lead candidate ATR inhibitors gartisertib (VX-803) and berzosertib (VE-822) in our dataset.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification | |
Compound class | Synthetic organic |
International Nonproprietary Names | |
INN number | INN |
12189 | tuvusertib |
Synonyms |
compound I-C-79 [WO2014089379A1] |
Database Links | |
BindingDB Ligand | 412025 |
CAS Registry No. | 1613200-51-3 (source: WHO INN record) |
GtoPdb PubChem SID | 472319204 |
PubChem CID | 90199447 |
Search Google for chemical match using the InChIKey | RBQPCTBFIPVIJN-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | RBQPCTBFIPVIJN |
Search PubMed clinical trials | tuvusertib |
Search PubMed titles | tuvusertib |
Search PubMed titles/abstracts | tuvusertib |
UniChem Compound Search for chemical match using the InChIKey | RBQPCTBFIPVIJN-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | RBQPCTBFIPVIJN-UHFFFAOYSA-N |