Compound class:
Synthetic organic
Comment: QC-01-175 is a functional degrader of pathogenic tau protein [1]. It is a bifunctional molecule that simultaneously engages tau and cereblon (CRBN; a component of the E3 ubiquitin ligase complex) to trigger tau ubiquitination and proteasomal degradation. Such molecules can be described as PROTACs (proteolysis targeting chimeras). Cereblon engagement is mediated by the probe's pomalidomide module, and tau recruitment is achieved by a variant of the tau PET tracer T807 (flortaucipir (18F)). QC-01-175 retains the tau ligand-binding capacity of the parent T807, but with reduced off-target MAO inhibition liability.
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Classification ![]() |
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Compound class | Synthetic organic |
Ligand families/groups | PROTACs, molecular glues and other degraders |
Database Links ![]() |
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GtoPdb PubChem SID | 387065621 |
PubChem CID | 139593563 |
Search Google for chemical match using the InChIKey | NWTCZTAQSRLSCP-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | NWTCZTAQSRLSCP |
UniChem Compound Search for chemical match using the InChIKey | NWTCZTAQSRLSCP-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | NWTCZTAQSRLSCP-UHFFFAOYSA-N |
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QC-01–175 (links to external site)
Cat. No. HY-134850 |