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ChEMBL ligand: CHEMBL508207 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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CCR4/C-C chemokine receptor type 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2414] [GtoPdb: 61] [UniProtKB: P51679] | ||||||||
ChEMBL | Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis | F | 6.85 | pIC50 | 140 | nM | IC50 | Bioorg. Med. Chem. (2009) 17: 64-73 [PMID:19081254] |
ChEMBL | Displacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPA | B | 7.14 | pIC50 | 73 | nM | IC50 | Bioorg. Med. Chem. (2008) 16: 7021-7032 [PMID:18539035] |
GtoPdb | - | - | 7.74 | pIC50 | 18 | nM | IC50 | Bioorg Med Chem (2009) 17: 64-73 [PMID:19081254] |
ChEMBL | Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding | F | 7.74 | pIC50 | 18 | nM | IC50 | Bioorg. Med. Chem. (2009) 17: 64-73 [PMID:19081254] |
ChEMBL | Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay | F | 7.74 | pIC50 | 18 | nM | IC50 | Bioorg. Med. Chem. (2008) 16: 7021-7032 [PMID:18539035] |
CCR4/C-C chemokine receptor type 4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5410] [GtoPdb: 61] [UniProtKB: P51680] | ||||||||
ChEMBL | Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis | F | 7.41 | pIC50 | 39 | nM | IC50 | Bioorg. Med. Chem. (2009) 17: 64-73 [PMID:19081254] |
ChEMBL data shown on this page come from version 28:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]