compound 8ic [PMID: 19081254] [Ligand Id: 9478] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL508207 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CCR4/C-C chemokine receptor type 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2414] [GtoPdb: 61] [UniProtKB: P51679] | ||||||||
| ChEMBL | Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis | F | 6.85 | pIC50 | 140 | nM | IC50 | Bioorg Med Chem (2009) 17: 64-73 [PMID:19081254] |
| ChEMBL | Displacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPA | B | 7.14 | pIC50 | 73 | nM | IC50 | Bioorg Med Chem (2008) 16: 7021-7032 [PMID:18539035] |
| GtoPdb | - | - | 7.74 | pIC50 | 18 | nM | IC50 | Bioorg Med Chem (2009) 17: 64-73 [PMID:19081254] |
| ChEMBL | Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding | F | 7.74 | pIC50 | 18 | nM | IC50 | Bioorg Med Chem (2009) 17: 64-73 [PMID:19081254] |
| ChEMBL | Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay | F | 7.74 | pIC50 | 18 | nM | IC50 | Bioorg Med Chem (2008) 16: 7021-7032 [PMID:18539035] |
| CCR4/C-C chemokine receptor type 4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5410] [GtoPdb: 61] [UniProtKB: P51680] | ||||||||
| ChEMBL | Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis | F | 7.41 | pIC50 | 39 | nM | IC50 | Bioorg Med Chem (2009) 17: 64-73 [PMID:19081254] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
