compound 8ic [PMID: 19081254] [Ligand Id: 9478] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL508207
  • CCR4/C-C chemokine receptor type 4 in Human [ChEMBL: CHEMBL2414] [GtoPdb: 61] [UniProtKB: P51679]
  • CCR4/C-C chemokine receptor type 4 in Mouse [ChEMBL: CHEMBL5410] [GtoPdb: 61] [UniProtKB: P51680]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CCR4/C-C chemokine receptor type 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2414] [GtoPdb: 61] [UniProtKB: P51679]
ChEMBL Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis F 6.85 pIC50 140 nM IC50 Bioorg. Med. Chem. (2009) 17: 64-73 [PMID:19081254]
ChEMBL Displacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPA B 7.14 pIC50 73 nM IC50 Bioorg. Med. Chem. (2008) 16: 7021-7032 [PMID:18539035]
GtoPdb - - 7.74 pIC50 18 nM IC50 Bioorg Med Chem (2009) 17: 64-73 [PMID:19081254]
ChEMBL Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding F 7.74 pIC50 18 nM IC50 Bioorg. Med. Chem. (2009) 17: 64-73 [PMID:19081254]
ChEMBL Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay F 7.74 pIC50 18 nM IC50 Bioorg. Med. Chem. (2008) 16: 7021-7032 [PMID:18539035]
CCR4/C-C chemokine receptor type 4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5410] [GtoPdb: 61] [UniProtKB: P51680]
ChEMBL Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis F 7.41 pIC50 39 nM IC50 Bioorg. Med. Chem. (2009) 17: 64-73 [PMID:19081254]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]