(+)-ADTN [Ligand Id: 932] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL26736
  • D1 receptor in Human [GtoPdb: 214] [UniProtKB: P21728]
  • D1 receptor/Dopamine D1 receptor in Rat [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901]
  • This target only has 1 pki data point
  • 0
1 CHEMBL26736_lig_chart_1 D1 receptor HumanRat
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  • Dopamine D2 receptor in Bovine [ChEMBL: CHEMBL3998] [UniProtKB: P20288]
  • D2 receptor/Dopamine D2 receptor in Rat [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
  • This target only has 1 pki data point
  • 7.18
2 CHEMBL26736_lig_chart_2 Dopamine D2 receptor BovineRat
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  • D5 receptor in Human [GtoPdb: 218] [UniProtKB: P21918]
  • This target only has 1 pki data point
  • 6
3 CHEMBL26736_lig_chart_3 D5 receptor Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
D1 receptor in Human [GtoPdb: 214] [UniProtKB: P21728]
GtoPdb - - 6.4 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666];
Nature (1991) 350: 614-9 [PMID:1826762]
D1 receptor/Dopamine D1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901]
ChEMBL Affinity for Dopamine receptor D1 binding sites was evaluated in a test involving displacement of [3H]- fenoldopam in rat striatum B 7.15 pKd 0.07 uM K Bind J. Med. Chem. (1986) 29: 1615-1627 [PMID:2875183]
Dopamine D2 receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3998] [UniProtKB: P20288]
ChEMBL Affinity for Dopamine receptor D2 was evaluated from the ability to displace [3H]spiroperidol from homogenized bovine pituitary B 6.68 pKd 0.21 uM K Bind J. Med. Chem. (1986) 29: 1615-1627 [PMID:2875183]
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
ChEMBL Competitive binding assay against Dopamine receptor D2 in rat striatal membranes and [125I]-IBF radioligand B 7.18 pKi 65.7 nM Ki J. Med. Chem. (1990) 33: 171-178 [PMID:2136916]
ChEMBL Inhibition of specific binding of [3H]spiroperidol to Dopamine receptor D2 in rat striatal membranes B 6.15 pIC50 700 nM IC50 J. Med. Chem. (1998) 41: 4165-4170 [PMID:9767652]
D5 receptor in Human [GtoPdb: 218] [UniProtKB: P21918]
GtoPdb - - 6 pKi - - - Nature (1991) 350: 614-9 [PMID:1826762]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]