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ChEMBL ligand: CHEMBL1215923 (Bimosiamose, TBC-1269) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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selectin P (CD62)/P-selectin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5378] [GtoPdb: 3103] [UniProtKB: P16109] | ||||||||
ChEMBL | Inhibition of human P-selectin after 2 hrs | B | 4.02 | pIC50 | 95000 | nM | IC50 | J Med Chem (2007) 50: 1101-1115 [PMID:17302397] |
GtoPdb | Inhibition of P-selectin binding in an HL-60 cellular assay. | - | 4.15 | pIC50 | 70000 | nM | IC50 | J Med Chem (1998) 41: 1099-111 [PMID:9544210] |
ChEMBL | Inhibition of P-selectin in human HL-60 cells | B | 4.15 | pIC50 | 70000 | nM | IC50 | J Med Chem (2010) 53: 6003-6017 [PMID:20718494] |
P-selectin glycoprotein ligand 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4183] [UniProtKB: Q14242] | ||||||||
ChEMBL | Inhibition of P-selectin-mediated adhesion of HL60 cells | B | 4.15 | pIC50 | 70000 | nM | IC50 | J Med Chem (2007) 50: 21-39 [PMID:17201408] |
ChEMBL data shown on this page come from version 32:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]