bimosiamose [Ligand Id: 9049] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1215923 (Bimosiamose, TBC-1269)
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  • P-selectin glycoprotein ligand 1 in Human [ChEMBL: CHEMBL4183] [UniProtKB: Q14242]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
selectin P (CD62)/P-selectin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5378] [GtoPdb: 3103] [UniProtKB: P16109]
ChEMBL Inhibition of human P-selectin after 2 hrs B 4.02 pIC50 95000 nM IC50 J. Med. Chem. (2007) 50: 1101-1115 [PMID:17302397]
GtoPdb Inhibition of P-selectin binding in an HL-60 cellular assay. - 4.15 pIC50 70000 nM IC50 J Med Chem (1998) 41: 1099-111 [PMID:9544210]
ChEMBL Inhibition of P-selectin in human HL-60 cells B 4.15 pIC50 70000 nM IC50 J. Med. Chem. (2010) 53: 6003-6017 [PMID:20718494]
P-selectin glycoprotein ligand 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4183] [UniProtKB: Q14242]
ChEMBL Inhibition of P-selectin-mediated adhesion of HL60 cells B 4.15 pIC50 70000 nM IC50 J. Med. Chem. (2007) 50: 21-39 [PMID:17201408]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]