ChEMBL ligand: CHEMBL1412853
nucleotide binding oligomerization domain containing 1/Nucleotide-binding oligomerization domain-containing protein 1 in Human [ChEMBL: CHEMBL1293222] [GtoPdb: 1762] [UniProtKB: Q9Y239] There should be some charts here, you may need to enable JavaScript!
nucleotide binding oligomerization domain containing 2/Nucleotide-binding oligomerization domain-containing protein 2 in Human [ChEMBL: CHEMBL1293266] [GtoPdb: 1763] [UniProtKB: Q9HC29] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
nucleotide binding oligomerization domain containing 1/Nucleotide-binding oligomerization domain-containing protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293222] [GtoPdb: 1762] [UniProtKB: Q9Y239]
ChEMBL	Antagonist activity at human NOD1 expressed in HEK293 cells assessed as reduction in C12-iE-DAP-induced NF-kappaB activation preincubated for 1 hr followed by C12-iE-DAP stimulation and measured after 18 hrs by SEAP reporter gene based spectrophotometric analysis	B	6.11	pIC50	771	nM	IC50	Eur J Med Chem (2020) 190: 112089-112089 [PMID:32014680]
GtoPdb	-	-	6.25	pIC50	560	nM	IC50	ACS Med Chem Lett (2011) 2: 780-785 [PMID:22003428]
ChEMBL	Inhibition of NOD-1 mediated NFkappaB activation in HEK293T cells assessed as inhibition of gamma-tri-DAP-induced luciferase activity after 14 hrs by reporter gene assay	B	6.25	pIC50	560	nM	IC50	ACS Med Chem Lett (2011) 2: 780-785 [PMID:22003428]
ChEMBL	Inhibition of NOD1 (unknown origin) expressed in HEK293T cells coexpressing NF-kappaB driven luciferase reporter gene by HTS primary assay	B	6.25	pIC50	560	nM	IC50	J Med Chem (2014) 57: 6897-6918 [PMID:24707857]
ChEMBL	Inhibition of human NOD1 over-expressed in HEK-Blue cells assessed as inhibition of C12-iE-DAP induced NF-kappaB transcriptional activity preincubated for 1 hr followed by addition of C12-iE-DAP measured after 18 hrs by SEAP reporter gene assay	B	6.25	pIC50	560	nM	IC50	Bioorg Med Chem (2016) 24: 5221-5234 [PMID:27601373]
nucleotide binding oligomerization domain containing 2/Nucleotide-binding oligomerization domain-containing protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293266] [GtoPdb: 1763] [UniProtKB: Q9HC29]
ChEMBL	Inhibition of human NOD2 over-expressed in HEK-Blue cells assessed as inhibition of C12-iE-DAP induced NF-kappaB transcriptional activity preincubated for 1 hr followed by addition of C12-iE-DAP measured after 18 hrs by SEAP reporter gene assay	B	4.26	pIC50	54900	nM	IC50	Bioorg Med Chem (2016) 24: 5221-5234 [PMID:27601373]
ChEMBL	Antagonist activity at human NOD2 expressed in HEK293 cells assessed as reduction in MDP-induced NF-kappaB activation preincubated for 1 hr followed by MDP stimulation and measured after 18 hrs by SEAP reporter gene based spectrophotometric analysis	B	4.26	pIC50	54900	nM	IC50	Eur J Med Chem (2020) 190: 112089-112089 [PMID:32014680]
ChEMBL	Inhibition of NOD-2 mediated NFkappaB activation in HEK293T cells assessed as inhibition of MDP-induced luciferase activity after 14 hrs by reporter gene assay	B	4.7	pIC50	>20000	nM	IC50	ACS Med Chem Lett (2011) 2: 780-785 [PMID:22003428]
ChEMBL	Inhibition of NOD2 (unknown origin) expressed in HEK293T cells coexpressing NF-kappaB driven luciferase reporter gene by HTS primary assay	B	4.7	pIC50	>20000	nM	IC50	J Med Chem (2014) 57: 6897-6918 [PMID:24707857]
GtoPdb	-	-	4.7	pIC50	>20000	nM	IC50	ACS Med Chem Lett (2011) 2: 780-785 [PMID:22003428]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]