L-740093 [Ligand Id: 881] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL420783 (L-740093) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CCK1 receptor/Cholecystokinin A receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2871] [GtoPdb: 76] [UniProtKB: P30551] | ||||||||
| GtoPdb | - | - | 5.8 | pKi | - | - | - | Mol Pharmacol (1994) 46: 943-8 [PMID:7969084] |
| ChEMBL | Displacement of [125I]-BH CCK-8S from Cholecystokinin type A receptor in rat pancreas | B | 5.79 | pIC50 | 1604 | nM | IC50 | Bioorg Med Chem Lett (1995) 5: 3023-3026 |
| ChEMBL | Inhibition of ligand binding to Cholecystokinin type A receptor from rat pancreatic tissue. | B | 5.8 | pIC50 | 1600 | nM | IC50 | J Med Chem (1997) 40: 2491-2501 [PMID:9258356] |
| CCK2 receptor/Cholecystokinin B receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL298] [GtoPdb: 77] [UniProtKB: P32239] | ||||||||
| GtoPdb | - | - | 9.2 | pIC50 | 0.63 | nM | IC50 | Regul Pept (2002) 103: 29-37 [PMID:11738246] |
| ChEMBL | Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex | B | 10 | pIC50 | 0.1 | nM | IC50 | Bioorg Med Chem Lett (1995) 5: 3023-3026 |
| ChEMBL | Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane. | B | 10 | pIC50 | 0.1 | nM | IC50 | J Med Chem (1997) 40: 2491-2501 [PMID:9258356] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
