sotuletinib [Ligand Id: 8250] activity data from GtoPdb

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  • platelet derived growth factor receptor beta in Human [GtoPdb: 1804] [UniProtKB: P09619]
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  • KIT proto-oncogene, receptor tyrosine kinase in Human [GtoPdb: 1805] [UniProtKB: P10721]
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  • colony stimulating factor 1 receptor in Human [GtoPdb: 1806] [UniProtKB: P07333]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
platelet derived growth factor receptor beta in Human [GtoPdb: 1804] [UniProtKB: P09619]
GtoPdb - - 5.23 pIC50 5860 nM IC50 Oncoimmunology (2013) 2: e26968 [PMID:24498562]
KIT proto-oncogene, receptor tyrosine kinase in Human [GtoPdb: 1805] [UniProtKB: P10721]
GtoPdb - - 5.41 pIC50 3880 nM IC50 Oncoimmunology (2013) 2: e26968 [PMID:24498562]
colony stimulating factor 1 receptor in Human [GtoPdb: 1806] [UniProtKB: P07333]
GtoPdb - - 8.47 pKd 3.4 nM Kd J Med Chem (2020) : [PMID:32787110]
GtoPdb - - 9 pIC50 1 nM IC50 Oncoimmunology (2013) 2: e26968 [PMID:24498562]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.