PF-03715455 [Ligand Id: 8179] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1938400 (Pf-03715455, PF-03715455, Pf-3715455) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mitogen-activated protein kinase 11/MAP kinase p38 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3961] [GtoPdb: 1500] [UniProtKB: Q15759] | ||||||||
| ChEMBL | Inhibition of p38beta MAPK | B | 7.64 | pIC50 | 23 | nM | IC50 | J Med Chem (2011) 54: 7797-7814 [PMID:21888439] |
| misshapen like kinase 1/Misshapen-like kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5518] [GtoPdb: 2103] [UniProtKB: Q8N4C8] | ||||||||
| GtoPdb | - | - | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (2011) 54: 7797-814 [PMID:21888439] |
| ChEMBL | Inhibition of MINK | B | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (2011) 54: 7797-7814 [PMID:21888439] |
| fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948] | ||||||||
| ChEMBL | Inhibition of human VEGFR1 | B | 6.05 | pIC50 | 890 | nM | IC50 | J Med Chem (2011) 54: 7797-7814 [PMID:21888439] |
| mitogen-activated protein kinase 14 in Human [GtoPdb: 1499] [UniProtKB: Q16539] | ||||||||
| GtoPdb | - | - | 12 | pKd | 0 | nM | Kd | J Med Chem (2011) 54: 7797-814 [PMID:21888439] |
| GtoPdb | - | - | 9.06 | pIC50 | 0.88 | nM | IC50 | J Med Chem (2011) 54: 7797-814 [PMID:21888439] |
| mitogen-activated protein kinase 13 in Human [GtoPdb: 1502] [UniProtKB: O15264] | ||||||||
| GtoPdb | - | - | 7.64 | pIC50 | 23 | nM | IC50 | J Med Chem (2011) 54: 7797-814 [PMID:21888439] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
