PF-03715455 [Ligand Id: 8179] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1938400 (Pf-03715455, PF-03715455)
  • mitogen-activated protein kinase 11/MAP kinase p38 beta in Human [ChEMBL: CHEMBL3961] [GtoPdb: 1500] [UniProtKB: Q15759]
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  • misshapen like kinase 1/Misshapen-like kinase 1 in Human [ChEMBL: CHEMBL5518] [GtoPdb: 2103] [UniProtKB: Q8N4C8]
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  • fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948]
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  • mitogen-activated protein kinase 14 in Human [GtoPdb: 1499] [UniProtKB: Q16539]
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  • mitogen-activated protein kinase 13 in Human [GtoPdb: 1502] [UniProtKB: O15264]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mitogen-activated protein kinase 11/MAP kinase p38 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3961] [GtoPdb: 1500] [UniProtKB: Q15759]
ChEMBL Inhibition of p38beta MAPK B 7.64 pIC50 23 nM IC50 J. Med. Chem. (2011) 54: 7797-7814 [PMID:21888439]
misshapen like kinase 1/Misshapen-like kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5518] [GtoPdb: 2103] [UniProtKB: Q8N4C8]
GtoPdb - - 8.22 pIC50 6 nM IC50 J Med Chem (2011) 54: 7797-814 [PMID:21888439]
ChEMBL Inhibition of MINK B 8.22 pIC50 6 nM IC50 J. Med. Chem. (2011) 54: 7797-7814 [PMID:21888439]
fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948]
ChEMBL Inhibition of human VEGFR1 B 6.05 pIC50 890 nM IC50 J. Med. Chem. (2011) 54: 7797-7814 [PMID:21888439]
mitogen-activated protein kinase 14 in Human [GtoPdb: 1499] [UniProtKB: Q16539]
GtoPdb - - 12 pKd 0 nM Kd J Med Chem (2011) 54: 7797-814 [PMID:21888439]
GtoPdb - - 9.06 pIC50 0.88 nM IC50 J Med Chem (2011) 54: 7797-814 [PMID:21888439]
mitogen-activated protein kinase 13 in Human [GtoPdb: 1502] [UniProtKB: O15264]
GtoPdb - - 7.64 pIC50 23 nM IC50 J Med Chem (2011) 54: 7797-814 [PMID:21888439]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]