compound 7 [PMID: 22464456] [Ligand Id: 8172] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2017556
  • IL2 inducible T cell kinase/Tyrosine-protein kinase ITK/TSK in Human [ChEMBL: CHEMBL2959] [GtoPdb: 2046] [UniProtKB: Q08881]
  • This target only has 0 pki data point
  • 0
1 CHEMBL2017556_lig_chart_1 Tyrosine-protein kinase ITK/TSK Human
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  • LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239]
  • This target only has 0 pki data point
  • 0
2 CHEMBL2017556_lig_chart_2 Tyrosine-protein kinase LCK Human
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  • spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405]
  • This target only has 0 pki data point
  • 0
3 CHEMBL2017556_lig_chart_3 Tyrosine-protein kinase SYK Human
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  • TXK tyrosine kinase/Tyrosine-protein kinase TXK in Human [ChEMBL: CHEMBL4367] [GtoPdb: 2268] [UniProtKB: P42681]
  • This target only has 0 pki data point
  • 0
4 CHEMBL2017556_lig_chart_4 Tyrosine-protein kinase TXK Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
IL2 inducible T cell kinase/Tyrosine-protein kinase ITK/TSK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2959] [GtoPdb: 2046] [UniProtKB: Q08881]
GtoPdb - - 9.52 pIC50 0.3 nM IC50 Bioorg Med Chem Lett (2012) 22: 3296-300 [PMID:22464456]
ChEMBL Inhibition of recombinant N-terminus His6 tagged Itk (357-620) autophosphorylation expressed in insect Sf9 cells using [33P]ATP by scintillation counting B 9.52 pIC50 0.3 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 3296-3300 [PMID:22464456]
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239]
ChEMBL Inhibition of Lck autophosphorylation using [33P]ATP by scintillation counting B 7.41 pIC50 39.2 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 3296-3300 [PMID:22464456]
GtoPdb - - 7.41 pIC50 39.2 nM IC50 Bioorg Med Chem Lett (2012) 22: 3296-300 [PMID:22464456]
spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405]
ChEMBL Inhibition of recombinant N-terminus His6 tagged Syk (343 to 635) autophosphorylation expressed in insect Sf9 cells using [33P]ATP by scintillation counting B 6.45 pIC50 358.2 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 3296-3300 [PMID:22464456]
GtoPdb - - 6.45 pIC50 358.2 nM IC50 Bioorg Med Chem Lett (2012) 22: 3296-300 [PMID:22464456]
TXK tyrosine kinase/Tyrosine-protein kinase TXK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4367] [GtoPdb: 2268] [UniProtKB: P42681]
GtoPdb - - 7.11 pIC50 77.5 nM IC50 Bioorg Med Chem Lett (2012) 22: 3296-300 [PMID:22464456]
ChEMBL Inhibition of Txk autophosphorylation using [33P]ATP by scintillation counting B 7.11 pIC50 77.5 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 3296-3300 [PMID:22464456]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]