ChEMBL ligand: CHEMBL2017556
IL2 inducible T cell kinase/Tyrosine-protein kinase ITK/TSK in Human [ChEMBL: CHEMBL2959] [GtoPdb: 2046] [UniProtKB: Q08881] There should be some charts here, you may need to enable JavaScript!
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] There should be some charts here, you may need to enable JavaScript!
spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405] There should be some charts here, you may need to enable JavaScript!
TXK tyrosine kinase/Tyrosine-protein kinase TXK in Human [ChEMBL: CHEMBL4367] [GtoPdb: 2268] [UniProtKB: P42681] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
IL2 inducible T cell kinase/Tyrosine-protein kinase ITK/TSK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2959] [GtoPdb: 2046] [UniProtKB: Q08881]
GtoPdb	-	-	9.52	pIC50	0.3	nM	IC50	Bioorg Med Chem Lett (2012) 22: 3296-300 [PMID:22464456]
ChEMBL	Inhibition of recombinant N-terminus His6 tagged Itk (357-620) autophosphorylation expressed in insect Sf9 cells using [33P]ATP by scintillation counting	B	9.52	pIC50	0.3	nM	IC50	Bioorg Med Chem Lett (2012) 22: 3296-3300 [PMID:22464456]
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239]
ChEMBL	Inhibition of Lck autophosphorylation using [33P]ATP by scintillation counting	B	7.41	pIC50	39.2	nM	IC50	Bioorg Med Chem Lett (2012) 22: 3296-3300 [PMID:22464456]
GtoPdb	-	-	7.41	pIC50	39.2	nM	IC50	Bioorg Med Chem Lett (2012) 22: 3296-300 [PMID:22464456]
spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405]
ChEMBL	Inhibition of recombinant N-terminus His6 tagged Syk (343 to 635) autophosphorylation expressed in insect Sf9 cells using [33P]ATP by scintillation counting	B	6.45	pIC50	358.2	nM	IC50	Bioorg Med Chem Lett (2012) 22: 3296-3300 [PMID:22464456]
GtoPdb	-	-	6.45	pIC50	358.2	nM	IC50	Bioorg Med Chem Lett (2012) 22: 3296-300 [PMID:22464456]
TXK tyrosine kinase/Tyrosine-protein kinase TXK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4367] [GtoPdb: 2268] [UniProtKB: P42681]
GtoPdb	-	-	7.11	pIC50	77.5	nM	IC50	Bioorg Med Chem Lett (2012) 22: 3296-300 [PMID:22464456]
ChEMBL	Inhibition of Txk autophosphorylation using [33P]ATP by scintillation counting	B	7.11	pIC50	77.5	nM	IC50	Bioorg Med Chem Lett (2012) 22: 3296-3300 [PMID:22464456]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]