AZD6703 [Ligand Id: 7687] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2031465 (AZ-12012199, AZD-6703)
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  • mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG B 4 pIC50 >100000 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 3879-3883 [PMID:22608965]
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
ChEMBL Inhibition of p38alpha-mediated TNFalpha secretion in LPS-stimulated human whole blood B 7.56 pIC50 27.54 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 3879-3883 [PMID:22608965]
ChEMBL Inhibition of p38alpha-mediated TNFalpha secretion in LPS-stimulated human whole blood B 7.57 pIC50 27 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 3879-3883 [PMID:22608965]
ChEMBL Inhibition of p38alpha-mediated TNFalpha secretion in LPS-stimulated human whole blood assessed as IC50 equals to free drug concentration at human whole blood IC50 B 7.76 pIC50 17.38 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 3879-3883 [PMID:22608965]
ChEMBL Inhibition of p38alpha kinase B 7.8 pIC50 16 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 3879-3883 [PMID:22608965]
ChEMBL Inhibition of p38alpha kinase B 7.8 pIC50 15.85 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 3879-3883 [PMID:22608965]
GtoPdb - - 7.81 pIC50 15.58 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 3879-83 [PMID:22608965]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]