umeclidinium | Ligand Activity Charts | IUPHAR/BPS Guide to PHARMACOLOGY

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Ligand Activity Charts

umeclidinium [Ligand Id: 7354] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1187833 (GSK573719, GSK-573719, Umeclidinium, Umeclidinium cation, Umeclidinium ion)
M₁ receptor in Human [GtoPdb: 13] [UniProtKB: P11229] There should be some charts here, you may need to enable JavaScript!
M₂ receptor in Human [GtoPdb: 14] [UniProtKB: P08172] There should be some charts here, you may need to enable JavaScript!
M₃ receptor in Human [GtoPdb: 15] [UniProtKB: P20309] There should be some charts here, you may need to enable JavaScript!
M₄ receptor in Human [GtoPdb: 16] [UniProtKB: P08173] There should be some charts here, you may need to enable JavaScript!
M₅ receptor in Human [GtoPdb: 17] [UniProtKB: P08912] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
M₁ receptor in Human [GtoPdb: 13] [UniProtKB: P11229]
GtoPdb	-	-	9.8	pKi	0.16	nM	Ki	J Med Chem (2009) 52: 2493-505 [PMID:19317446]; J Pharmacol Exp Ther (2013) 345: 260-70 [PMID:23435542]
M₂ receptor in Human [GtoPdb: 14] [UniProtKB: P08172]
GtoPdb	-	-	9.82	pKi	0.15	nM	Ki	J Med Chem (2009) 52: 2493-505 [PMID:19317446]; J Pharmacol Exp Ther (2013) 345: 260-70 [PMID:23435542]
M₃ receptor in Human [GtoPdb: 15] [UniProtKB: P20309]
GtoPdb	-	-	10.22	pKi	0.06	nM	Ki	J Med Chem (2009) 52: 2493-505 [PMID:19317446]; J Pharmacol Exp Ther (2013) 345: 260-70 [PMID:23435542]
M₄ receptor in Human [GtoPdb: 16] [UniProtKB: P08173]
GtoPdb	-	-	10.3	pKi	-	-	-	J Pharmacol Exp Ther (2013) 345: 260-70 [PMID:23435542]
M₅ receptor in Human [GtoPdb: 17] [UniProtKB: P08912]
GtoPdb	-	-	9.9	pKi	-	-	-	J Pharmacol Exp Ther (2013) 345: 260-70 [PMID:23435542]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]