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ChEMBL ligand: CHEMBL1187833 (GSK573719, GSK-573719, Umeclidinium, Umeclidinium cation, Umeclidinium ion) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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M1 receptor in Human [GtoPdb: 13] [UniProtKB: P11229] | ||||||||
GtoPdb | - | - | 9.8 | pKi | 0.16 | nM | Ki |
J Med Chem (2009) 52: 2493-505 [PMID:19317446]; J Pharmacol Exp Ther (2013) 345: 260-70 [PMID:23435542] |
M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172] | ||||||||
GtoPdb | - | - | 9.82 | pKi | 0.15 | nM | Ki |
J Med Chem (2009) 52: 2493-505 [PMID:19317446]; J Pharmacol Exp Ther (2013) 345: 260-70 [PMID:23435542] |
M3 receptor in Human [GtoPdb: 15] [UniProtKB: P20309] | ||||||||
GtoPdb | - | - | 10.22 | pKi | 0.06 | nM | Ki |
J Med Chem (2009) 52: 2493-505 [PMID:19317446]; J Pharmacol Exp Ther (2013) 345: 260-70 [PMID:23435542] |
M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173] | ||||||||
GtoPdb | - | - | 10.3 | pKi | - | - | - | J Pharmacol Exp Ther (2013) 345: 260-70 [PMID:23435542] |
M5 receptor in Human [GtoPdb: 17] [UniProtKB: P08912] | ||||||||
GtoPdb | - | - | 9.9 | pKi | - | - | - | J Pharmacol Exp Ther (2013) 345: 260-70 [PMID:23435542] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]