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ChEMBL ligand: CHEMBL628 (BL 191, BL-191, C04AD03, Neotren mr, NSC-637086, NSC-758481, Oxpentifylline, Oxypentifylline, Pentoxifylline, Pentoxil, Pentoxiphyllin, Trental, Trental 100, Trental 400) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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acetylcholinesterase (Cartwright blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] | ||||||||
ChEMBL | Inhibition of human AChE using acetylthiocholine iodide as substrate treated 5 mins before substrate addition measured up to 4 mins by Ellman's method | B | 5.18 | pIC50 | 6600 | nM | IC50 | Bioorg. Med. Chem. Lett. (2013) 23: 4336-4341 [PMID:23791077] |
A2B receptor/Adenosine A2b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275] | ||||||||
ChEMBL | Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand | B | 5.29 | pKi | 5180 | nM | Ki | J. Med. Chem. (2002) 45: 2131-2138 [PMID:12014951] |
GtoPdb | - | - | 5.29 | pKi | 5180 | nM | Ki | J Med Chem (2002) 45: 2131-8 [PMID:12014951] |
butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276] | ||||||||
ChEMBL | Inhibition of human BuChE using S-butyrylthiocholine iodide as substrate treated 5 mins before substrate addition measured up to 4 mins by Ellman's method | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg. Med. Chem. Lett. (2013) 23: 4336-4341 [PMID:23791077] |
phosphodiesterase 4B/Phosphodiesterase 4B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343] | ||||||||
ChEMBL | Inhibition of human GST-tagged PDE4B expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiesterase Assay | B | 4.05 | pIC50 | >90000 | nM | IC50 | Eur J Med Chem (2018) 146: 381-394 [PMID:29407965] |
TNF-alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1825] [UniProtKB: P01375] | ||||||||
ChEMBL | TNF-alpha production in PBMC by ELISA method | F | 4.07 | pIC50 | 85000 | nM | IC50 | J. Med. Chem. (1996) 39: 2-9 [PMID:8568809] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]