dimethyl fumarate [Ligand Id: 7045] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2107333 (AZL 0 211089, AZL-0211089, AZL O 211089, AZL-O-211089, BG 00012, BG-00012, BG00012, BG 12, BG-12, Dimethyl fumar, Dimethyl fumarate, Dimethyl fumarate neuraxpharm, FAG-201, FP-187, FP187, Fumaric acid dimethyl ester, Las41008, LAS-41008, LAS41008, NSC-167432, NSC-25942, Panaclar, Tecfidera) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| nuclear factor, erythroid 2 like 2/Nuclear factor erythroid 2-related factor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075094] [GtoPdb: 3057] [UniProtKB: Q16236] | ||||||||
| ChEMBL | Activation of Nrf2 in human PathHunter U2OS Keap1-Nrf2 cells assessed as Nrf2 nuclear translocation by chemiluminescent assay | B | 5.1 | pEC50 | 7930 | nM | EC50 | ACS Med Chem Lett (2023) 14: 1700-1706 [PMID:38116420] |
| ChEMBL | Activation of Nrf2 in human U2OS cells co-expressing Keap1 assessed as induction of Nrf2 nuclear translocation incubated for 6 hrs by PathHunter chemiluminescence based analysis | B | 5.29 | pEC50 | 5114 | nM | EC50 | Eur J Med Chem (2023) 256: 115433-115433 [PMID:37187090] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
