[3H]folinic acid [Ligand Id: 6690] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1679 (Leucovorin)
  • dihydrofolate reductase/Dihydrofolate reductase in Human [ChEMBL: CHEMBL202] [GtoPdb: 2603] [UniProtKB: P00374]
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  • Solute carrier organic anion transporter family member 1A3 in Rat [ChEMBL: CHEMBL2073707] [UniProtKB: P70502]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
dihydrofolate reductase/Dihydrofolate reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL202] [GtoPdb: 2603] [UniProtKB: P00374]
ChEMBL Tested for the inhibition of [14C]-DDATHF influx in CCRF-CEM cells of human leukemic lymphoblast B 5.63 pKi 2370 nM Ki J. Med. Chem. (1994) 37: 2167-2174 [PMID:8035423]
Solute carrier organic anion transporter family member 1A3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073707] [UniProtKB: P70502]
ChEMBL TP_TRANSPORTER: inhibition of MTX uptake in OAT-K1-expressing MDCK cells F 5.09 pKi 8200 nM Ki J. Pharmacol. Exp. Ther. (2000) 293: 1034-1039 [PMID:10869408]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]