[3H]folinic acid [Ligand Id: 6690] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1679 (Leucovorin)
  • dihydrofolate reductase/Dihydrofolate reductase in Human [ChEMBL: CHEMBL202] [GtoPdb: 2603] [UniProtKB: P00374]
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  • Solute carrier organic anion transporter family member 1A3 in Rat [ChEMBL: CHEMBL2073707] [UniProtKB: P70502]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
dihydrofolate reductase/Dihydrofolate reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL202] [GtoPdb: 2603] [UniProtKB: P00374]
ChEMBL Tested for the inhibition of [14C]-DDATHF influx in CCRF-CEM cells of human leukemic lymphoblast B 5.63 pKi 2370 nM Ki J Med Chem (1994) 37: 2167-2174 [PMID:8035423]
Solute carrier organic anion transporter family member 1A3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073707] [UniProtKB: P70502]
ChEMBL TP_TRANSPORTER: inhibition of MTX uptake in OAT-K1-expressing MDCK cells F 5.09 pKi 8200 nM Ki J Pharmacol Exp Ther (2000) 293: 1034-1039 [PMID:10869408]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]