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ChEMBL ligand: CHEMBL1679 (Leucovorin) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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dihydrofolate reductase/Dihydrofolate reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL202] [GtoPdb: 2603] [UniProtKB: P00374] | ||||||||
ChEMBL | Tested for the inhibition of [14C]-DDATHF influx in CCRF-CEM cells of human leukemic lymphoblast | B | 5.63 | pKi | 2370 | nM | Ki | J. Med. Chem. (1994) 37: 2167-2174 [PMID:8035423] |
Solute carrier organic anion transporter family member 1A3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073707] [UniProtKB: P70502] | ||||||||
ChEMBL | TP_TRANSPORTER: inhibition of MTX uptake in OAT-K1-expressing MDCK cells | F | 5.09 | pKi | 8200 | nM | Ki | J. Pharmacol. Exp. Ther. (2000) 293: 1034-1039 [PMID:10869408] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]