BMS-561392 [Ligand Id: 6509] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL489100 (BMS-561392) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ADAM10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5028] [GtoPdb: 1658] [UniProtKB: O14672] | ||||||||
| ChEMBL | Inhibition of ADAM10 (unknown origin) using fluorescent substrate by fluorescence-based FRET assay | B | 6.32 | pIC50 | 480 | nM | IC50 | Medchemcomm (2011) 2: 966-972 |
| ADAM17 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3706] [GtoPdb: 1662] [UniProtKB: P78536] | ||||||||
| ChEMBL | Inhibition of human catalytic domain of TACE assessed as inhibit the cleavage of the substrate by fluorescence-based FRET assay | B | 7.92 | pIC50 | 12 | nM | IC50 | Medchemcomm (2011) 2: 966-972 |
| GtoPdb | - | - | 8.7 | pIC50 | 2 | nM | IC50 | Bioorg Med Chem (2009) 17: 444-59 [PMID:19095454] |
| ChEMBL | Inhibition of TACE | B | 9.7 | pIC50 | 0.2 | nM | IC50 | Bioorg Med Chem (2009) 17: 444-459 [PMID:19095454] |
| MMP1/Matrix metalloproteinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956] | ||||||||
| ChEMBL | Inhibition of MMP1 (unknown origin) by fluorescence-based FRET assay | B | 6.37 | pIC50 | 429 | nM | IC50 | Medchemcomm (2011) 2: 966-972 |
| MMP13/Matrix metalloproteinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452] | ||||||||
| ChEMBL | Inhibition of MMP13 (unknown origin) by fluorescence-based FRET assay | B | 6.34 | pIC50 | 461 | nM | IC50 | Medchemcomm (2011) 2: 966-972 |
| MMP14/Matrix metalloproteinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281] | ||||||||
| ChEMBL | Inhibition of MMP14 (unknown origin) by fluorescence-based FRET assay | B | 6.3 | pIC50 | 499 | nM | IC50 | Medchemcomm (2011) 2: 966-972 |
| MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253] | ||||||||
| ChEMBL | Inhibition of MMP2 (unknown origin) by fluorescence-based FRET assay | B | 6.32 | pIC50 | 482 | nM | IC50 | Medchemcomm (2011) 2: 966-972 |
| MMP3/Matrix metalloproteinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254] | ||||||||
| ChEMBL | Inhibition of MMP3 (unknown origin) by fluorescence-based FRET assay | B | 6.55 | pIC50 | 285 | nM | IC50 | Medchemcomm (2011) 2: 966-972 |
| MMP7/Matrix metalloproteinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4073] [GtoPdb: 1631] [UniProtKB: P09237] | ||||||||
| ChEMBL | Inhibition of MMP7 (unknown origin) by fluorescence-based FRET assay | B | 6.33 | pIC50 | 466 | nM | IC50 | Medchemcomm (2011) 2: 966-972 |
| MMP8/Matrix metalloproteinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4588] [GtoPdb: 1632] [UniProtKB: P22894] | ||||||||
| ChEMBL | Inhibition of MMP8 (unknown origin) by fluorescence-based FRET assay | B | 6.52 | pIC50 | 299 | nM | IC50 | Medchemcomm (2011) 2: 966-972 |
| MMP9/Matrix metalloproteinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780] | ||||||||
| ChEMBL | Inhibition of MMP9 (unknown origin) by fluorescence-based FRET assay | B | 6.41 | pIC50 | 389 | nM | IC50 | Medchemcomm (2011) 2: 966-972 |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
