fasidotrilat [Ligand Id: 6502] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL325055
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  • Neutral endopeptidase in Human [GtoPdb: 1611] [UniProtKB: P08473]
  • Neutral endopeptidase/Neprilysin in Rat [ChEMBL: CHEMBL3369] [GtoPdb: 1611] [UniProtKB: P07861]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Angiotensin-converting enzyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1808] [GtoPdb: 1613] [UniProtKB: P12821]
GtoPdb - - 8 pKi 9.8 nM Ki Med Chem (2005) 1: 71-104 [PMID:16789888]
ChEMBL Inhibitory activity against angiotensin I converting enzyme (ACE) B 8.01 pKi 9.8 nM Ki J. Med. Chem. (2000) 43: 305-341 [PMID:10669559]
Neutral endopeptidase in Human [GtoPdb: 1611] [UniProtKB: P08473]
GtoPdb - - 8.3 pKi 5.6 nM Ki Med Chem (2005) 1: 321-6 [PMID:16789889]
Neutral endopeptidase/Neprilysin in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3369] [GtoPdb: 1611] [UniProtKB: P07861]
ChEMBL Inhibitory activity against neutral Endopeptidase B 8.25 pKi 5.6 nM Ki J. Med. Chem. (2000) 43: 305-341 [PMID:10669559]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]