[Leu8,des-Arg9]bradykinin [Ligand Id: 641] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL80472 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| B1 receptor/Bradykinin B1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4308] [GtoPdb: 41] [UniProtKB: P46663] | ||||||||
| ChEMBL | Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin. | B | 6.42 | pKi | 382 | nM | Ki | J Med Chem (2000) 43: 2382-2386 [PMID:10882364] |
| GtoPdb | - | - | 7.2 | pKi | - | - | - |
J Biol Chem (1997) 272: 11420-5 [PMID:9111052]; J Biol Chem (1994) 269: 21583-21586 [PMID:8063797]; Eur J Pharmacol (1999) 374: 423-433 [PMID:10422787]; Br J Pharmacol (1997) 122: 393-9 [PMID:9313952]; Mol Pharmacol (1997) 51: 171-6 [PMID:9203620] |
| B1 receptor in Mouse [GtoPdb: 41] [UniProtKB: Q61125] | ||||||||
| GtoPdb | - | - | 8.4 | pKi | - | - | - | Immunopharmacology (1996) 33: 1-8 [PMID:8856107] |
| GtoPdb | - | - | 7.3 | pEC50 | - | - | - | Can J Physiol Pharmacol (1997) 75: 735-740 [PMID:9276157] |
| GtoPdb | - | - | 6.9 | pA2 | - | - | - | Can J Physiol Pharmacol (1995) 73: 1759-64 [PMID:8834490] |
| B1 receptor in Rat [GtoPdb: 41] [UniProtKB: P97583] | ||||||||
| GtoPdb | - | - | 7.7 | pKi | - | - | - | Eur J Pharmacol (1999) 374: 423-433 [PMID:10422787] |
| B2 receptor/Bradykinin B2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3157] [GtoPdb: 42] [UniProtKB: P30411] | ||||||||
| ChEMBL | Ability to bind to human cloned B2 receptor in competition binding experiments with [3H]- bradykinin | B | 8 | pKi | >10 | nM | Ki | J Med Chem (2000) 43: 2382-2386 [PMID:10882364] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
