bortezomib [Ligand Id: 6391] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL325041 (Bortezomib, Bortezomib accord, Bortezomib hydrate, LDP-341, NSC-681239, PS-341, Velcade) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| proteasome 20S subunit beta 1/proteasome 20S subunit beta 8/proteasome 20S subunit beta 9/proteasome 20S subunit beta 6/proteasome 20S subunit beta 5/proteasome 20S subunit beta 2/20S proteasome in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL3831201] [GtoPdb: 2404, 2408, 2409, 2407, 2406, 2405] [UniProtKB: A5LHX3, O14818, P20618, P25786, P25787, P25788, P25789, P28062, P28065, P28066, P28070, P28072, P28074, P40306, P49720, P49721, P60900, Q8TAA3, Q99436] | ||||||||
| ChEMBL | Inhibition of human erythrocytes 20S proteasome using QXL520-YRGITCSGRQK(5-FAM)-NH2 fluorogenic peptide as substrate preincubated for 10 mins followed by substrate addition and measured after 60 mins by HTRF assay | B | 7.01 | pIC50 | 97 | nM | IC50 | J Med Chem (2021) 64: 4857-4869 [PMID:33821636] |
| GtoPdb | - | - | 7.7 | pIC50 | 20 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 3220-4 [PMID:19428245] |
| ChEMBL | Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate addition | B | 7.97 | pIC50 | 10.8 | nM | IC50 | Eur J Med Chem (2019) 164: 602-614 [PMID:30639896] |
| ChEMBL | Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu Leu-Val-Tyr-AMC as substrate preincubated for 15 mins followed by substrate addition measured by fluorescence assay | B | 8.16 | pIC50 | 6.91 | nM | IC50 | Eur J Med Chem (2022) 233: 114211-114211 [PMID:35218994] |
| proteasome 26S subunit, non-ATPase 14/proteasome 20S subunit beta 1/proteasome 20S subunit beta 8/proteasome 20S subunit beta 9/proteasome 20S subunit beta 6/proteasome 20S subunit beta 5/proteasome 20S subunit beta 2/26S proteasome in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2364701] [GtoPdb: 2410, 2404, 2408, 2409, 2407, 2406, 2405] [UniProtKB: A5LHX3, O00231, O00232, O00487, O14818, O43242, P17980, P20618, P25786, P25787, P25788, P25789, P28062, P28065, P28066, P28070, P28072, P28074, P35998, P40306, P43686, P48556, P49720, P49721, P51665, P55036, P60896, P60900, P62191, P62195, P62333, Q13200, Q15008, Q16186, Q8TAA3, Q99436, Q99460, Q9UNM6] | ||||||||
| ChEMBL | Inhibition of trypsin-like activity of human 20S proteasome using Ac-RLR-AMC as substrate | B | 5.7 | pIC50 | 2000 | nM | IC50 | J Med Chem (2014) 57: 2726-2735 [PMID:24524217] |
| ChEMBL | Inhibition of caspase-like activity of human 20S proteasome using Ac-nLPnLD-AMC as substrate | B | 6.92 | pIC50 | 120 | nM | IC50 | J Med Chem (2014) 57: 2726-2735 [PMID:24524217] |
| GtoPdb | - | - | 7.7 | pIC50 | 20 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 3220-4 [PMID:19428245] |
| ChEMBL | Inhibition of chymotrypsin-like enzyme activity of purified human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate by fluorescence method | B | 8.15 | pIC50 | 7.14 | nM | IC50 | Bioorg Med Chem (2014) 22: 2955-2965 [PMID:24767818] |
| ChEMBL | Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-LLVY-AMC as substrate | B | 8.15 | pIC50 | 7 | nM | IC50 | J Med Chem (2014) 57: 2726-2735 [PMID:24524217] |
| ChEMBL | Inhibition of human 20S proteasome using Suc-LLVY-AMC as substrate preincubated for 30 mins followed by substrate addition measured after 90 mins by fluorescence assay | B | 8.59 | pIC50 | 2.56 | nM | IC50 | Medchemcomm (2011) 2: 1083-1086 |
| ChEMBL | Inhibition of 26S proteasome (unknown origin) | B | 8.62 | pIC50 | 2.4 | nM | IC50 | ACS Med Chem Lett (2024) 15: 501-509 [PMID:38628785] |
| Alpha-chymotrypsin in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3314] [UniProtKB: P00766] | ||||||||
| ChEMBL | Inhibition of bovine pancreatic alpha-chymotrypsin using Suc-Leu-Leu-Val-Tyr-AMC as substrate by fluorescence assay | B | 5.62 | pKi | 2400 | nM | Ki | Eur J Med Chem (2014) 83: 1-14 [PMID:24946214] |
| ATP-dependent Clp protease proteolytic subunit in Staphylococcus aureus (strain NCTC 8325) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1932910] [UniProtKB: Q2G036] | ||||||||
| ChEMBL | Inhibition of N-terminal His6-sumo-tagged full length Staphylococcus aureus ClpP expressed in Escherichia coli BL2 (DE3) pre-incubated for 10 mins before Suc-LY-AMC addition and measured after 1 hr by fluorescence based assay | B | 5.28 | pIC50 | 5300 | nM | IC50 | J Med Chem (2020) 63: 3104-3119 [PMID:32031798] |
| ChEMBL | Inhibition of ClpP in methicillin-resistant Staphylococcus aureus ATCC 33591 assessed as reduction in bacteria-induced hemolysis of sheep erythrocytes by measuring hemoglobin release incubated for 15 mins | B | 4.63 | pEC50 | 23500 | nM | EC50 | J Med Chem (2020) 63: 3104-3119 [PMID:32031798] |
| chymotrypsinogen B1/Beta-chymotrypsin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4796] [GtoPdb: 3272] [UniProtKB: P17538] | ||||||||
| ChEMBL | Inhibitory activity against human Chymotrypsinogen | B | 6.49 | pKi | 320 | nM | Ki | Bioorg Med Chem Lett (1998) 8: 333-338 [PMID:9871680] |
| Carbonic anhydrase 15 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23] | ||||||||
| ChEMBL | Inhibition of mouse CA15 by stopped-flow CO2 hydrase assay | B | 5.57 | pKi | 2680 | nM | Ki | Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280] |
| carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase-1 preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 5.89 | pKi | 1290 | nM | Ki | Bioorg Med Chem (2016) 24: 4406-4409 [PMID:27469982] |
| ChEMBL | Inhibition of human CA1 by stopped-flow CO2 hydrase assay | B | 5.89 | pKi | 1290 | nM | Ki | Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280] |
| carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase-2 preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 5.94 | pKi | 1160 | nM | Ki | Bioorg Med Chem (2016) 24: 4406-4409 [PMID:27469982] |
| ChEMBL | Inhibition of human CA2 by stopped-flow CO2 hydrase assay | B | 5.94 | pKi | 1160 | nM | Ki | Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280] |
| Carbonic anhydrase III in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2885] [UniProtKB: P07451] | ||||||||
| ChEMBL | Inhibition of human CA3 by stopped-flow CO2 hydrase assay | B | 5.34 | pKi | 4570 | nM | Ki | Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280] |
| carbonic anhydrase 4/Carbonic anhydrase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748] | ||||||||
| ChEMBL | Inhibition of human CA4 by stopped-flow CO2 hydrase assay | B | 5.19 | pKi | 6510 | nM | Ki | Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280] |
| carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] | ||||||||
| ChEMBL | Inhibition of human CA9 by stopped-flow CO2 hydrase assay | B | 5.47 | pKi | 3380 | nM | Ki | Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280] |
| carbonic anhydrase 5A/Carbonic anhydrase VA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218] | ||||||||
| ChEMBL | Inhibition of human CA5A by stopped-flow CO2 hydrase assay | B | 5.16 | pKi | 6920 | nM | Ki | Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280] |
| Carbonic anhydrase VB in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0] | ||||||||
| ChEMBL | Inhibition of human CA5B by stopped-flow CO2 hydrase assay | B | 5.17 | pKi | 6830 | nM | Ki | Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280] |
| Carbonic anhydrase VI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280] | ||||||||
| ChEMBL | Inhibition of human CA6 by stopped-flow CO2 hydrase assay | B | 5.36 | pKi | 4380 | nM | Ki | Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280] |
| carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166] | ||||||||
| ChEMBL | Inhibition of human CA7 by stopped-flow CO2 hydrase assay | B | 5.16 | pKi | 6940 | nM | Ki | Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280] |
| carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570] | ||||||||
| ChEMBL | Inhibition of human CA12 by stopped-flow CO2 hydrase assay | B | 5.23 | pKi | 5870 | nM | Ki | Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280] |
| carbonic anhydrase 13/Carbonic anhydrase XIII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3912] [GtoPdb: 2748] [UniProtKB: Q8N1Q1] | ||||||||
| ChEMBL | Inhibition of human CA13 by stopped-flow CO2 hydrase assay | B | 5.07 | pKi | 8450 | nM | Ki | Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280] |
| carbonic anhydrase 14/Carbonic anhydrase XIV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7] | ||||||||
| ChEMBL | Inhibition of human CA14 by stopped-flow CO2 hydrase assay | B | 5.48 | pKi | 3280 | nM | Ki | Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280] |
| cathepsin B/Cathepsin B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4072] [GtoPdb: 2343] [UniProtKB: P07858] | ||||||||
| ChEMBL | Inhibition of recombinant cathepsin B (unknown origin) using Z-Leu-Arg-AMC as substrate by spectrofluorometer analysis | B | 4.52 | pIC50 | >30000 | nM | IC50 | J Med Chem (2014) 57: 2726-2735 [PMID:24524217] |
| cathepsin G/Cathepsin G in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4071] [GtoPdb: 2348] [UniProtKB: P08311] | ||||||||
| ChEMBL | Inhibitory activity against human cathepsin G | B | 6.2 | pKi | 630 | nM | Ki | Bioorg Med Chem Lett (1998) 8: 333-338 [PMID:9871680] |
| ChEMBL | Inhibition of recombinant cathepsin G (unknown origin) using Suc-Ala-Ala-Pro-Phe-AMC as substrate by spectrofluorometer analysis | B | 5.51 | pIC50 | 3100 | nM | IC50 | J Med Chem (2014) 57: 2726-2735 [PMID:24524217] |
| ChEMBL | Inhibition of human cathepsin G | B | 6.28 | pIC50 | 520 | nM | IC50 | J Med Chem (2008) 51: 1068-1072 [PMID:18247547] |
| chymase 1/Chymase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4068] [GtoPdb: 2340] [UniProtKB: P23946] | ||||||||
| ChEMBL | Inhibition of human chymase | B | 5.92 | pIC50 | 1190 | nM | IC50 | J Med Chem (2008) 51: 1068-1072 [PMID:18247547] |
| histone deacetylase 1/Histone deacetylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547] | ||||||||
| ChEMBL | Inhibition of HDAC1 in human RPMI-8226 cells incubated for 2 hrs by ELISA | B | 6.21 | pIC50 | 620 | nM | IC50 | Eur J Med Chem (2020) 189: 112062-112062 [PMID:31986406] |
| histone deacetylase 2/Histone deacetylase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769] | ||||||||
| ChEMBL | Inhibition of HDAC2 in human RPMI-8226 cells incubated for 2 hrs by ELISA | B | 6.1 | pIC50 | 800 | nM | IC50 | Eur J Med Chem (2020) 189: 112062-112062 [PMID:31986406] |
| histone deacetylase 3/Histone deacetylase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379] | ||||||||
| ChEMBL | Inhibition of HDAC3 in human RPMI-8226 cells incubated for 2 hrs by ELISA | B | 5.93 | pIC50 | 1180 | nM | IC50 | Eur J Med Chem (2020) 189: 112062-112062 [PMID:31986406] |
| histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] | ||||||||
| ChEMBL | Inhibition of HDAC6 in human RPMI-8226 cells incubated for 2 hrs by ELISA | B | 4.16 | pIC50 | 69440 | nM | IC50 | Eur J Med Chem (2020) 189: 112062-112062 [PMID:31986406] |
| histone deacetylase 8/Histone deacetylase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41] | ||||||||
| ChEMBL | Inhibition of HDAC8 in human RPMI-8226 cells incubated for 2 hrs by ELISA | B | 7.14 | pIC50 | 72 | nM | IC50 | Eur J Med Chem (2020) 189: 112062-112062 [PMID:31986406] |
| elastase, neutrophil expressed/Leukocyte elastase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL248] [GtoPdb: 2358] [UniProtKB: P08246] | ||||||||
| ChEMBL | Inhibitory activity against human leukocyte elastase | B | 5.64 | pKi | 2300 | nM | Ki | Bioorg Med Chem Lett (1998) 8: 333-338 [PMID:9871680] |
| lon peptidase 1, mitochondrial/Lon protease homolog, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4879436] [GtoPdb: 3180] [UniProtKB: P36776] | ||||||||
| ChEMBL | Inhibition of LONP1 (unknown origin) using QXL520-YRGITCSGRQK(5-FAM)-NH2 peptide as substrate incubated for 50 mins in presence of ATP by HTRF assay | B | 6.74 | pIC50 | 183 | nM | IC50 | J Med Chem (2021) 64: 4857-4869 [PMID:33821636] |
| Cathepsin A/Lysosomal protective protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6115] [GtoPdb: 1581] [UniProtKB: P10619] | ||||||||
| ChEMBL | Inhibition of recombinant cathepsin A (unknown origin) using Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(Dnp)-OH as substrate incubated with enzyme for 5 mins prior to substrate challenge for 2 hrs by spectrofluorometer analysis | B | 5.04 | pIC50 | 9200 | nM | IC50 | J Med Chem (2014) 57: 2726-2735 [PMID:24524217] |
| NLRP3/NACHT, LRR and PYD domains-containing protein 3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3779755] [GtoPdb: 1770] [UniProtKB: Q8R4B8] | ||||||||
| ChEMBL | Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 1 hr followed by nigericin stimulation and measured after 1 hr by ELISA | B | 7.39 | pIC50 | 40.74 | nM | IC50 | J Med Chem (2022) 65: 11985-12001 [PMID:36063115] |
| nuclear factor kappa B subunit 1/nuclear factor kappa B subunit 2/RELA proto-oncogene, NF-kB subunit/Nuclear factor NF-kappa-B complex in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094258] [GtoPdb: 3281, 3282, 3280] [UniProtKB: P19838, Q00653, Q04206] | ||||||||
| ChEMBL | Inhibition of TNFalpha-induced NFkappaB activation in HEK293 cells assessed as luciferase expression by luciferase reporter activity assay | B | 7.07 | pIC50 | 85 | nM | IC50 | Bioorg Med Chem Lett (2021) 42: 128042-128042 [PMID:33862226] |
| ChEMBL | Inhibition of NFkappaB in HEK293 cells incubated for 1 hr prior to TNF-alpha challenge measured after 3 hrs by luciferase reporter gene assay relative to control | B | 8.01 | pIC50 | 9.7 | nM | IC50 | Medchemcomm (2012) 3: 710-719 |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimalarial activity against erythrocytic stage of Plasmodium falciparum Dd2 harboring 20S beta5 proteasome A49S mutant measured after 72 hrs by SYBR green dye based fluorescence assay | F | 5.99 | pEC50 | 1024 | nM | EC50 | J Med Chem (2019) 62: 6137-6145 [PMID:31177777] |
| ChEMBL | Antimalarial activity against erythrocytic stage of Plasmodium falciparum Dd2 measured after 72 hrs by SYBR green dye based fluorescence assay | F | 6.38 | pEC50 | 419 | nM | EC50 | J Med Chem (2019) 62: 6137-6145 [PMID:31177777] |
| ChEMBL | Antimalarial activity against erythrocytic stage of Plasmodium falciparum Dd2 harboring 20S beta2 proteasome A117D mutant measured after 72 hrs by SYBR green dye based fluorescence assay | F | 6.97 | pEC50 | 106 | nM | EC50 | J Med Chem (2019) 62: 6137-6145 [PMID:31177777] |
| proteasome 20S subunit beta 1/Proteasome component C5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4208] [GtoPdb: 2404] [UniProtKB: P20618] | ||||||||
| ChEMBL | Inhibition of 20S proteasome beta1 subunit in human erythrocytes using Z-LLE-AMC as substrate by fluorescence assay | B | 5 | pIC50 | >10000 | nM | IC50 | Medchemcomm (2012) 3: 710-719 |
| ChEMBL | Inhibition of PGPH activity of human 20S proteasome using Z-LLE-MCA as substrate measured for 1 hr by fluorescence assay | B | 6.15 | pIC50 | 700 | nM | IC50 | Eur J Med Chem (2018) 146: 636-650 [PMID:29407987] |
| ChEMBL | Inhibition of 20S proteasome beta1 subunit (unknown origin) using Z-LLE-AMC as flurogenic substrate measured after 1 hr by fluorescence based analysis | B | 6.53 | pIC50 | 296.7 | nM | IC50 | J Med Chem (2022) 65: 11985-12001 [PMID:36063115] |
| ChEMBL | Inhibition of caspase-like activity of human 20S proteasome beta 1 subunit using Ac-nLPnLD-AMC as substrate after 60 mins by fluorescence assay | B | 6.89 | pIC50 | 130 | nM | IC50 | J Med Chem (2013) 56: 3689-3700 [PMID:23547757] |
| ChEMBL | Inhibition of human hepatic cell derived 20s constitutive proteasome beta1 caspase-like activity using Suc-LLE-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by fluorescence assay | B | 6.98 | pIC50 | 104 | nM | IC50 | Eur J Med Chem (2019) 164: 423-439 [PMID:30611983] |
| ChEMBL | Inhibition of caspase-like activity of human 20S proteasome | B | 7.02 | pIC50 | 96.5 | nM | IC50 | Bioorg Med Chem (2018) 26: 3975-3981 [PMID:29934218] |
| ChEMBL | Inhibition of human 20S constitutive proteasome beta 1 subunit caspase-like activity using fluorogenic peptide Ac-nLPnLD-AMC as substrate in presence of PA28alpha incubated for 1 to 2 hrs by fluorescence microplate reader assay | B | 7.05 | pIC50 | 90 | nM | IC50 | J Med Chem (2018) 61: 10053-10066 [PMID:30373366] |
| ChEMBL | Inhibition of 20S proteasome beta 1c (unknown origin) after 1 hr by fluorescence based assay | B | 7.15 | pIC50 | 70 | nM | IC50 | Eur J Med Chem (2019) 182: 111646-111646 [PMID:31521028] |
| ChEMBL | Reversible inhibition of human erythrocyte derived 20S proteasome subunit beta1 after 30 mins by fluorogenic assay | B | 7.28 | pIC50 | 53 | nM | IC50 | J Med Chem (2012) 55: 10317-10327 [PMID:22978849] |
| ChEMBL | Inhibition of caspase-like activity of 20S proteasome in human HL60 cells using Z-nLPnLDaminoluciferin as substrate after 2 hrs by fluorescence analysis | B | 7.52 | pIC50 | 30 | nM | IC50 | Eur J Med Chem (2017) 125: 925-939 [PMID:27769033] |
| ChEMBL | Inhibition of beta 1 proteasome (unknown origin) | B | 7.62 | pIC50 | 24 | nM | IC50 | J Med Chem (2021) 64: 2851-2877 [PMID:33656892] |
| ChEMBL | Inhibition of PGPH activity of human 26S proteasome using Z-LLE-MCA as substrate measured for 1 hr by fluorescence assay | B | 7.72 | pIC50 | 19 | nM | IC50 | Eur J Med Chem (2018) 146: 636-650 [PMID:29407987] |
| proteasome 20S subunit beta 2/Proteasome Macropain subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3492] [GtoPdb: 2405] [UniProtKB: P49721] | ||||||||
| ChEMBL | Inhibition of trypsin-like activity of human 26S proteasome using Boc-LRR-MCA as substrate measured for 1 hr by fluorescence assay | B | 4.4 | pIC50 | >40000 | nM | IC50 | Eur J Med Chem (2018) 146: 636-650 [PMID:29407987] |
| ChEMBL | Inhibition of 20S proteasome beta2 subunit in human erythrocytes using Ac-KQL-AMC as substrate by fluorescence assay | B | 5 | pIC50 | >10000 | nM | IC50 | Medchemcomm (2012) 3: 710-719 |
| ChEMBL | Inhibition of trypsin-like activity of human 20S proteasome | B | 5.4 | pIC50 | 3998 | nM | IC50 | Bioorg Med Chem (2018) 26: 3975-3981 [PMID:29934218] |
| ChEMBL | Inhibition of human hepatic cell derived 20s constitutive proteasome beta2 trypsin-like activity using Suc-LLE-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by fluorescence assay | B | 5.67 | pIC50 | 2119 | nM | IC50 | Eur J Med Chem (2019) 164: 423-439 [PMID:30611983] |
| ChEMBL | Inhibition of trypsin-like activity of human 20S proteasome using Boc-LRR-MCA as substrate measured for 1 hr by fluorescence assay | B | 5.71 | pIC50 | 1930 | nM | IC50 | Eur J Med Chem (2018) 146: 636-650 [PMID:29407987] |
| ChEMBL | Inhibition of trypsin-like activity of human 20S proteasome beta 2 subunit using Ac-RLR-AMC as substrate after 60 mins by fluorescence assay | B | 5.73 | pIC50 | 1880 | nM | IC50 | J Med Chem (2013) 56: 3689-3700 [PMID:23547757] |
| ChEMBL | Inhibition of 20S proteasome beta 2c (unknown origin) after 1 hr by fluorescence based assay | B | 5.82 | pIC50 | 1500 | nM | IC50 | Eur J Med Chem (2019) 182: 111646-111646 [PMID:31521028] |
| ChEMBL | Inhibition of beta2 proteasome (unknown origin) | B | 5.92 | pIC50 | 1200 | nM | IC50 | J Med Chem (2021) 64: 2851-2877 [PMID:33656892] |
| ChEMBL | Inhibition of human 20S constitutive proteasome beta 2 subunit trypsin-like activity using fluorogenic peptide Ac-WLR-AMC as substrate in presence of PA28alpha incubated for 1 to 2 hrs by fluorescence microplate reader assay | B | 5.92 | pIC50 | 1200 | nM | IC50 | J Med Chem (2018) 61: 10053-10066 [PMID:30373366] |
| ChEMBL | Reversible inhibition of human erythrocyte derived 20S proteasome subunit beta2 after 30 mins by fluorogenic assay | B | 6.23 | pIC50 | 590 | nM | IC50 | J Med Chem (2012) 55: 10317-10327 [PMID:22978849] |
| ChEMBL | Inhibition of trypsin-like activity of 20S proteasome in human HL60 cells using Z-LRRaminoluciferin as substrate after 2 hrs by fluorescence analysis | B | 6.36 | pIC50 | 440 | nM | IC50 | Eur J Med Chem (2017) 125: 925-939 [PMID:27769033] |
| ChEMBL | Inhibition of 20S proteasome beta2 subunit (unknown origin) using Boc-LRR-AMC as flurogenic substrate measured after 1 hr by fluorescence based analysis | B | 6.58 | pIC50 | 261.1 | nM | IC50 | J Med Chem (2022) 65: 11985-12001 [PMID:36063115] |
| ChEMBL | Inhibition of human 20s proteasome subunit beta2 caspase-like activity using Z-LLE-AMC as substrate preincubated for 15 mins followed by substrate addition | B | 6.89 | pIC50 | 128 | nM | IC50 | Eur J Med Chem (2019) 164: 602-614 [PMID:30639896] |
| proteasome 20S subunit beta 5/Proteasome Macropain subunit MB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4662] [GtoPdb: 2406] [UniProtKB: P28074] | ||||||||
| ChEMBL | Inhibition of chymotrypsin-like activity of human 20S proteasome beta 5 subunit assessed as Suc-Leu-Leu-Val-Tyr-AMC substrate hydrolysis after 10 mins by fluorometric analysis | B | 8.01 | pKi | 9.8 | nM | Ki | Eur J Med Chem (2014) 76: 1-9 [PMID:24561716] |
| ChEMBL | Inhibition of chymotrypsin-like activity of 20S proteasome in human erythrocytes using Suc-Leu-Leu-Val-Tyr-AMC as substrate by fluorescence assay | B | 8.01 | pKi | 9.8 | nM | Ki | Eur J Med Chem (2014) 83: 1-14 [PMID:24946214] |
| ChEMBL | Inhibition of human 20S proteasome chymotrypsin like activity using Suc-Leu-Leu-Val-Tyr-AMC as substrate measured over 10 mins by fluorescence assay | B | 9.22 | pKi | 0.6 | nM | Ki | Eur J Med Chem (2013) 64: 23-34 [PMID:23639651] |
| ChEMBL | Inhibition of 20S proteasome beta5 subunit (unknown origin) assessed as formation of reversible adduct with N-terminal threonine | B | 9.26 | pKi | 0.55 | nM | Ki | Medchemcomm (2012) 3: 710-719 |
| ChEMBL | Inhibition of chymotrypsin-like activity of human 26S proteasome using Suc-LLVY-MCA as substrate measured for 1 hr by fluorescence assay | B | 5.68 | pIC50 | 2100 | nM | IC50 | Eur J Med Chem (2018) 146: 636-650 [PMID:29407987] |
| ChEMBL | Inhibition of beta5 subunit of immunoproteasome (unknown origin) by active-site ELISA | B | 6.85 | pIC50 | 140 | nM | IC50 | J Med Chem (2014) 57: 2726-2735 [PMID:24524217] |
| ChEMBL | Inhibition of chymotrypsin-like activity of 20S proteasome in imatinib-resistant human SUP-B15 cells using Suc-LLVY aminoluciferin as substrate after 2 hrs by proteasome-Glo assay | B | 7.55 | pIC50 | 28.09 | nM | IC50 | J Med Chem (2018) 61: 10299-10309 [PMID:30365892] |
| GtoPdb | - | - | 7.7 | pIC50 | 20 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 3220-4 [PMID:19428245] |
| ChEMBL | Inhibition of human hepatic cell derived 20s constitutive proteasome beta5 chymotrypsin-like activity using Suc-WLA-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by fluorescence assay | B | 7.96 | pIC50 | 11 | nM | IC50 | Eur J Med Chem (2019) 164: 423-439 [PMID:30611983] |
| ChEMBL | Inhibition of human 20s constitutive proteasome beta5 chymotrypsin-like activity using Suc-LLVY-AMC as substrate preincubated for 15 mins followed by substrate addition | B | 7.97 | pIC50 | 10.8 | nM | IC50 | Eur J Med Chem (2019) 164: 602-614 [PMID:30639896] |
| ChEMBL | Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate after 1 hr by fluorescence analysis | B | 8.08 | pIC50 | 8.3 | nM | IC50 | Bioorg Med Chem Lett (2018) 28: 2148-2152 [PMID:29773504] |
| ChEMBL | Reversible inhibition of human erythrocyte derived 20S proteasome subunit beta5 after 30 mins by fluorogenic assay | B | 8.1 | pIC50 | 7.9 | nM | IC50 | J Med Chem (2012) 55: 10317-10327 [PMID:22978849] |
| ChEMBL | Inhibition of chymotrypsin like activity of human erythrocyte-derived 20S proteasome preincubated for 10 mins using Suc-LLVY-AMC as substrate after 60 mins by fluorescence assay | B | 8.15 | pIC50 | 7.09 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 1958-1962 [PMID:26965867] |
| ChEMBL | Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate incubated for 10 mins followed by substrate addition measured after 1 hr by spectrofluorimetric method | B | 8.15 | pIC50 | 7.04 | nM | IC50 | Bioorg Med Chem (2018) 26: 3975-3981 [PMID:29934218] |
| ChEMBL | Inhibition of 20S proteasome beta 5c (unknown origin) after 1 hr by fluorescence based assay | B | 8.15 | pIC50 | 7 | nM | IC50 | Eur J Med Chem (2019) 182: 111646-111646 [PMID:31521028] |
| ChEMBL | Inhibition of chymotrypsin-like activity of 20S proteasome in human HL60 cells using Suc-LLVY aminoluciferin as substrate after 2 hrs by proteasome-Glo assay | B | 8.18 | pIC50 | 6.67 | nM | IC50 | J Med Chem (2018) 61: 10299-10309 [PMID:30365892] |
| ChEMBL | Inhibition of human 20S proteasome chymotryptic-like activity using Suc-LLVY-AMC as substrate measured for 30 mins by fluorescence assay | B | 8.21 | pIC50 | 6.2 | nM | IC50 | Bioorg Med Chem (2016) 24: 2441-2450 [PMID:27112450] |
| ChEMBL | Inhibition of human 20S constitutive proteasome beta 5 subunit chymotrypsin-like activity using fluorogenic peptide Ac-WLA-AMC as substrate in presence of PA28alpha incubated for 1 to 2 hrs by fluorescence microplate reader assay | B | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (2018) 61: 10053-10066 [PMID:30373366] |
| ChEMBL | Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate by fluorescence assay | B | 8.33 | pIC50 | 4.68 | nM | IC50 | Eur J Med Chem (2017) 128: 180-191 [PMID:28182990] |
| ChEMBL | Inhibition of chymotrypsin-like activity of human 20S proteasome beta 5 subunit using Suc-LLVY-AMC as substrate after 60 mins by fluorescence assay | B | 8.35 | pIC50 | 4.5 | nM | IC50 | J Med Chem (2013) 56: 3689-3700 [PMID:23547757] |
| ChEMBL | Inhibition of chymotrypsin-like activity of 20S proteasome in human SEM cells using Suc-LLVY aminoluciferin as substrate after 2 hrs by proteasome-Glo assay | B | 8.35 | pIC50 | 4.43 | nM | IC50 | J Med Chem (2018) 61: 10299-10309 [PMID:30365892] |
| ChEMBL | Inhibition of chymotrypsin-like activity of 20S proteasome in human HL60 cells using Suc-LLVYaminoluciferin as substrate after 2 hrs by fluorescence analysis | B | 8.4 | pIC50 | 4 | nM | IC50 | Eur J Med Chem (2017) 125: 925-939 [PMID:27769033] |
| ChEMBL | Inhibition of chymotrypsin-like activity of 20S proteasome in human HL60 cells using Suc-LLVYaminoluciferin as substrate pretreated for 2 hrs followed by substrate addition by fluorescence assay | B | 8.4 | pIC50 | 4 | nM | IC50 | Bioorg Med Chem (2017) 25: 4031-4044 [PMID:28634039] |
| ChEMBL | Inhibition of chymotrypsin-like activity of 26S proteasome beta 5 subunit in human U266 cells using Suc-LLVY-aminoluciferin as substrate after 1 hr by Proteosome-Glo luminescence assay | B | 8.4 | pIC50 | 4 | nM | IC50 | Eur J Med Chem (2017) 135: 142-158 [PMID:28441582] |
| ChEMBL | Inhibition of 26S proteasome beta5 subunit in human Calu6 cells using Suc-LLVY-aminoluciferin as substrate after 1hr by luminescence assay | B | 8.41 | pIC50 | 3.9 | nM | IC50 | Medchemcomm (2012) 3: 710-719 |
| ChEMBL | Inhibition of human 20S proteasome beta5 subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and measured after 1 hr by fluorescence intensity assay | B | 8.49 | pIC50 | 3.2 | nM | IC50 | J Med Chem (2021) 64: 10230-10245 [PMID:34228444] |
| ChEMBL | Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based analysis | B | 8.55 | pIC50 | 2.82 | nM | IC50 | J Med Chem (2022) 65: 11985-12001 [PMID:36063115] |
| ChEMBL | Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based analysis | B | 8.55 | pIC50 | 2.8 | nM | IC50 | J Med Chem (2022) 65: 11985-12001 [PMID:36063115] |
| ChEMBL | Inhibition of beta5 proteasome (unknown origin) | B | 8.62 | pIC50 | 2.4 | nM | IC50 | J Med Chem (2021) 64: 2851-2877 [PMID:33656892] |
| ChEMBL | Inhibition of 20S proteasome beta5 subunit in human erythrocytes using Ac-WLA-AMC as substrate by fluorescence assay | B | 8.7 | pIC50 | 2 | nM | IC50 | Medchemcomm (2012) 3: 710-719 |
| ChEMBL | Inhibition of chymotrypsin like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 10 mins followed by substrate addition measured after 1 hr by spectrofluorimetric analysis | B | 8.72 | pIC50 | 1.9 | nM | IC50 | Bioorg Med Chem (2016) 24: 2576-2588 [PMID:27117691] |
| ChEMBL | Inhibition of chymotrypsin like activity of human 20S proteasome using ZGlyGlyLeuAMC/SucLeuLeuValTyrAMC as substrate measured every minute for 25 mins by fluorescence assay | B | 8.72 | pIC50 | 1.9 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 1958-1962 [PMID:26965867] |
| ChEMBL | Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-LLVY-MCA as substrate measured for 1 hr by fluorescence assay | B | 9.3 | pIC50 | 0.5 | nM | IC50 | Eur J Med Chem (2018) 146: 636-650 [PMID:29407987] |
| Proteasome subunit beta type-10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3317334] [UniProtKB: P40306] | ||||||||
| ChEMBL | Inhibition of human 20S immunoproteasome beta-2i subunit using Ac-RLR-AMC as substrate preincubated for 2 hrs followed by substrate addition and measured after 1 hr by fluorescence intensity assay | B | 5.79 | pIC50 | 1630 | nM | IC50 | J Med Chem (2021) 64: 10230-10245 [PMID:34228444] |
| ChEMBL | Inhibition of 20S proteasome beta 2i (unknown origin) after 1 hr by fluorescence based assay | B | 6.03 | pIC50 | 940 | nM | IC50 | Eur J Med Chem (2019) 182: 111646-111646 [PMID:31521028] |
| ChEMBL | Inhibition of human 20S immunoproteasome beta 2 subunit trypsin-like activity using fluorogenic peptide Ac-WLR-AMC as substrate in presence of PA28alpha incubated for 1 to 2 hrs by fluorescence microplate reader assay | B | 6.27 | pIC50 | 540 | nM | IC50 | J Med Chem (2018) 61: 10053-10066 [PMID:30373366] |
| proteasome 20S subunit beta 6/Proteasome subunit beta type-6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1944496] [GtoPdb: 2407] [UniProtKB: P28072] | ||||||||
| ChEMBL | Inhibition of human 20S immunoproteasome beta1 subunit using Ac-nLPnLD-AMC as substrate preincubated for 2 hrs followed by substrate addition and measured after 1 hr by fluorescence intensity assay | B | 7.6 | pIC50 | 25 | nM | IC50 | J Med Chem (2021) 64: 10230-10245 [PMID:34228444] |
| Proteasome subunit beta type-7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3347256] [UniProtKB: Q99436] | ||||||||
| ChEMBL | Inhibition of human 20S proteasome beta2 subunit using Ac-RLR-AMC as substrate preincubated for 2 hrs followed by substrate addition and measured after 1 hr by fluorescence intensity assay | B | 4.89 | pIC50 | 12769 | nM | IC50 | J Med Chem (2021) 64: 10230-10245 [PMID:34228444] |
| proteasome 20S subunit beta 8/Proteasome subunit beta type-8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5620] [GtoPdb: 2408] [UniProtKB: P28062] | ||||||||
| ChEMBL | Inhibition of beta5i subunit of immunoproteasome (unknown origin) by active-site ELISA | B | 7.11 | pIC50 | 78 | nM | IC50 | J Med Chem (2014) 57: 2726-2735 [PMID:24524217] |
| ChEMBL | Inhibition of chymotrypsin-like activity of LMP7 immunoproteasome by proteasome active site ELISA | B | 8.09 | pIC50 | 8.1 | nM | IC50 | J Med Chem (2009) 52: 3028-3038 [PMID:19348473] |
| ChEMBL | Inhibition of human 20s immunoproteasome beta5i activity using Suc-LLVY-AMC as substrate preincubated for 15 mins followed by substrate addition | B | 8.1 | pIC50 | 8 | nM | IC50 | Eur J Med Chem (2019) 164: 602-614 [PMID:30639896] |
| ChEMBL | Inhibition of human peripheral blood derived 20s immunoproteasome beta5 chymotrypsin-like activity using Suc-PAL-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by fluorescence assay | B | 8.4 | pIC50 | 4 | nM | IC50 | Eur J Med Chem (2019) 164: 423-439 [PMID:30611983] |
| ChEMBL | Inhibition of 20S proteasome beta 5i (unknown origin) after 1 hr by fluorescence based assay | B | 8.48 | pIC50 | 3.3 | nM | IC50 | Eur J Med Chem (2019) 182: 111646-111646 [PMID:31521028] |
| ChEMBL | Inhibition of human 20S immunoproteasome beta 5 subunit chymotrypsin-like activity using fluorogenic peptide Ac-WLA-AMC as substrate in presence of PA28alpha incubated for 1 to 2 hrs by fluorescence microplate reader assay | B | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (2018) 61: 10053-10066 [PMID:30373366] |
| ChEMBL | Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and measured after 1 hr by fluorescence intensity assay | B | 8.89 | pIC50 | 1.3 | nM | IC50 | J Med Chem (2021) 64: 10230-10245 [PMID:34228444] |
| proteasome 20S subunit beta 8/Proteasome subunit beta type-8 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1944492] [GtoPdb: 2408] [UniProtKB: P28063] | ||||||||
| ChEMBL | Inhibition of chymotrypsin like activity of mouse spleen 20S proteasome beta5i subunit using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 15 mins followed by substrate addition measured after 2 hrs by fluorescence-based assay | B | 7.77 | pIC50 | 16.8 | nM | IC50 | ACS Med Chem Lett (2016) 7: 1039-1043 [PMID:27994734] |
| proteasome 20S subunit beta 9/Proteasome subunit beta type-9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1944495] [GtoPdb: 2409] [UniProtKB: P28065] | ||||||||
| ChEMBL | Inhibition of 20S proteasome beta 1i (unknown origin) after 1 hr by fluorescence based assay | B | 8.26 | pIC50 | 5.5 | nM | IC50 | Eur J Med Chem (2019) 182: 111646-111646 [PMID:31521028] |
| ChEMBL | Inhibition of human 20S immunoproteasome beta 1 subunit caspase-like activity using fluorogenic peptide Ac-nLPnLD-AMC as substrate in presence of PA28alpha incubated for 1 to 2 hrs by fluorescence microplate reader assay | B | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (2018) 61: 10053-10066 [PMID:30373366] |
| ChEMBL | Inhibition of human peripheral blood derived 20s immunoproteasome beta1 caspase-like activity using Suc-PAL-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by fluorescence assay | B | 8.52 | pIC50 | 3 | nM | IC50 | Eur J Med Chem (2019) 164: 423-439 [PMID:30611983] |
| ChEMBL | Inhibition of human 20S immunoproteasome beta-1i subunit using (Ac-PAL)2R110 as substrate preincubated for 2 hrs followed by substrate addition and measured after 1 hr by fluorescence intensity assay | B | 8.54 | pIC50 | 2.9 | nM | IC50 | J Med Chem (2021) 64: 10230-10245 [PMID:34228444] |
| coagulation factor II, thrombin/Thrombin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734] | ||||||||
| ChEMBL | Inhibitory activity against thrombin | B | 4.89 | pKi | 13000 | nM | Ki | Bioorg Med Chem Lett (1998) 8: 333-338 [PMID:9871680] |
| Uncharacterized protein Rv1284/MT1322 in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5631] [UniProtKB: P9WPJ7] | ||||||||
| ChEMBL | Inhibition of Mycobacterium tuberculosis beta-carbonic anhydrase Rv1284 preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 5.14 | pKi | 7300 | nM | Ki | Bioorg Med Chem (2016) 24: 4406-4409 [PMID:27469982] |
| Plasmodium falciparum proteasome subunit beta type-5 in Plasmodium falciparum W2 [GtoPdb: 3088] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.37 | pIC50 | 43 | nM | IC50 | BMC Clin Pharmacol (2007) 7: 13 [PMID:17956613] |
| Plasmodium falciparum proteasome subunit beta type-5 in Plasmodium falciparum [GtoPdb: 3088] | ||||||||
| GtoPdb | - | - | 7.28 | pIC50 | 53 | nM | IC50 | J Med Chem (2018) 61: 10053-10066 [PMID:30373366] |
| Plasmodium falciparum proteasome subunit beta type-5 in Plasmodium falciparum 3D7 [GtoPdb: 3088] [UniProtKB: Q8IJT1] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.51 | pIC50 | 31 | nM | IC50 | BMC Clin Pharmacol (2007) 7: 13 [PMID:17956613] |
| Plasmodium falciparum proteasome subunit beta type-5 in Plasmodium falciparum Dd2 [GtoPdb: 3088] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.43 | pIC50 | 37 | nM | IC50 | BMC Clin Pharmacol (2007) 7: 13 [PMID:17956613] |
| Plasmodium falciparum proteasome subunit beta type-5 in Plasmodium falciparum HB3 [GtoPdb: 3088] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.51 | pIC50 | 31 | nM | IC50 | BMC Clin Pharmacol (2007) 7: 13 [PMID:17956613] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
