SU6656 [Ligand Id: 6044] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL605003 (SU-6656)
  • ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73]
  • This target only has 0 pki data point
  • 0
1 CHEMBL605003_lig_chart_1 ALK tyrosine kinase receptor Human
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  • BR serine/threonine kinase 2/BR serine/threonine-protein kinase 2 in Human [ChEMBL: CHEMBL4574] [GtoPdb: 1947] [UniProtKB: Q8IWQ3]
  • This target only has 0 pki data point
  • 0
2 CHEMBL605003_lig_chart_2 BR serine/threonine-protein kinase 2 Human
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  • Plasmodium falciparum [ChEMBL: CHEMBL364]
  • This target only has 0 pki data point
  • 0
3 CHEMBL605003_lig_chart_3 Plasmodium falciparum Plasmodium falciparum
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  • aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4]
  • This target only has 0 pki data point
  • 0
4 CHEMBL605003_lig_chart_4 Serine/threonine-protein kinase Aurora-B Human
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  • aurora kinase C/Serine/threonine-protein kinase Aurora-C in Human [ChEMBL: CHEMBL3935] [GtoPdb: 1938] [UniProtKB: Q9UQB9]
  • This target only has 0 pki data point
  • 0
5 CHEMBL605003_lig_chart_5 Serine/threonine-protein kinase Aurora-C Human
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  • serine/threonine kinase 3/Serine/threonine-protein kinase MST2 in Human [ChEMBL: CHEMBL4708] [GtoPdb: 2219] [UniProtKB: Q13188]
  • This target only has 0 pki data point
  • 0
6 CHEMBL605003_lig_chart_6 Serine/threonine-protein kinase MST2 Human
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  • ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519]
  • This target only has 0 pki data point
  • 0
7 CHEMBL605003_lig_chart_7 Tyrosine-protein kinase ABL Human
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  • FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241]
  • This target only has 0 pki data point
  • 0
8 CHEMBL605003_lig_chart_8 Tyrosine-protein kinase FYN Human
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  • LCK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2053] [UniProtKB: P06239]
  • LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Mouse [ChEMBL: CHEMBL2480] [GtoPdb: 2053] [UniProtKB: P06240]
  • This target only has 0 pki data point
  • 0
9 CHEMBL605003_lig_chart_9 LCK proto-oncogene, Src family tyrosine kinase HumanMouse
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  • LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948]
  • This target only has 0 pki data point
  • 0
10 CHEMBL605003_lig_chart_10 Tyrosine-protein kinase Lyn Human
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  • fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888]
  • This target only has 0 pki data point
  • 0
11 CHEMBL605003_lig_chart_11 Tyrosine-protein kinase receptor FLT3 Human
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  • ret proto-oncogene/Tyrosine-protein kinase receptor RET in Human [ChEMBL: CHEMBL2041] [GtoPdb: 2185] [UniProtKB: P07949]
  • This target only has 0 pki data point
  • 0
12 CHEMBL605003_lig_chart_12 Tyrosine-protein kinase receptor RET Human
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  • Tyrosine-protein kinase SRC in Chicken [ChEMBL: CHEMBL3655] [UniProtKB: P00523]
  • SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
  • This target only has 0 pki data point
  • 0
13 CHEMBL605003_lig_chart_13 Tyrosine-protein kinase SRC ChickenHuman
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  • YES proto-oncogene 1, Src family tyrosine kinase/Tyrosine-protein kinase YES in Human [ChEMBL: CHEMBL2073] [GtoPdb: 2284] [UniProtKB: P07947]
  • This target only has 0 pki data point
  • 0
14 CHEMBL605003_lig_chart_14 Tyrosine-protein kinase YES Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73]
ChEMBL Inhibition of ALK by ELISA-based kinase assay B 4.74 pIC50 18000 nM IC50 Bioorg. Med. Chem. (2010) 18: 1482-1496 [PMID:20117004]
ChEMBL Inhibition of ALK using FL-Peptide 13, 5-FAM-KKSRGDYMTMQIG-CONH2 substrate after 60 mins by mobility shift assay B 6.07 pIC50 850 nM IC50 Bioorg. Med. Chem. (2011) 19: 3086-3095 [PMID:21515061]
BR serine/threonine kinase 2/BR serine/threonine-protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4574] [GtoPdb: 1947] [UniProtKB: Q8IWQ3]
GtoPdb - - 7 pIC50 100 nM IC50 Biochem J (2007) 408: 297-315 [PMID:17850214]
ChEMBL Inhibition of BRSK2 in the presence of 50uM ATP B 7 pIC50 100 nM IC50 Biochem. J. (2007) 408: 297-315 [PMID:17850214]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay F 5.2 pIC50 6309.57 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay F 5.3 pIC50 5011.87 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay F 5.4 pIC50 3981.07 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay F 5.4 pIC50 3981.07 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay F 5.4 pIC50 3981.07 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay F 5.5 pIC50 3162.28 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay F 5.5 pIC50 3162.28 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4]
GtoPdb - - 7.72 pIC50 19 nM IC50 Biochem J (2007) 408: 297-315 [PMID:17850214]
ChEMBL Inhibition of Aurora B in the presence of 20uM ATP B 7.72 pIC50 19 nM IC50 Biochem. J. (2007) 408: 297-315 [PMID:17850214]
aurora kinase C/Serine/threonine-protein kinase Aurora-C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3935] [GtoPdb: 1938] [UniProtKB: Q9UQB9]
ChEMBL Inhibition of Aurora C in the presence of 5uM ATP B 7.77 pIC50 17 nM IC50 Biochem. J. (2007) 408: 297-315 [PMID:17850214]
GtoPdb - - 7.77 pIC50 17 nM IC50 Biochem J (2007) 408: 297-315 [PMID:17850214]
serine/threonine kinase 3/Serine/threonine-protein kinase MST2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4708] [GtoPdb: 2219] [UniProtKB: Q13188]
ChEMBL Inhibition of MST2 in the presence of 50uM ATP B 6.96 pIC50 110 nM IC50 Biochem. J. (2007) 408: 297-315 [PMID:17850214]
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519]
ChEMBL Inhibition of ABL by ELISA-based kinase assay B 4.3 pIC50 >50000 nM IC50 Bioorg. Med. Chem. (2010) 18: 1482-1496 [PMID:20117004]
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241]
ChEMBL Inhibition of Fyn B 6.77 pIC50 170 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-20528 [PMID:18077363]
LCK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2053] [UniProtKB: P06239]
GtoPdb - - 6.82 pIC50 150 nM IC50 Biochem J (2007) 408: 297-315 [PMID:17850214]
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2480] [GtoPdb: 2053] [UniProtKB: P06240]
ChEMBL Inhibition of Lck in the presence of 50uM ATP B 6.82 pIC50 150 nM IC50 Biochem. J. (2007) 408: 297-315 [PMID:17850214]
LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948]
ChEMBL Inhibition of Lyn kinase B 6.89 pIC50 130 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-20528 [PMID:18077363]
GtoPdb - - 6.89 pIC50 130 nM IC50 Proc Natl Acad Sci USA (2007) 104: 20523-8 [PMID:18077363]
fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888]
ChEMBL Inhibition of FLT3 by ELISA-based kinase assay B 5.06 pIC50 8700 nM IC50 Bioorg. Med. Chem. (2010) 18: 1482-1496 [PMID:20117004]
ret proto-oncogene/Tyrosine-protein kinase receptor RET in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2041] [GtoPdb: 2185] [UniProtKB: P07949]
ChEMBL Inhibition of human recombinant His-tagged RET expressed in Sf9 insect cells B 6.11 pIC50 770 nM IC50 Bioorg. Med. Chem. (2010) 18: 1482-1496 [PMID:20117004]
Tyrosine-protein kinase SRC in Chicken (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3655] [UniProtKB: P00523]
ChEMBL Inhibition of Src in the presence of 50uM ATP B 7 pIC50 100 nM IC50 Biochem. J. (2007) 408: 297-315 [PMID:17850214]
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
ChEMBL Inhibition of Src B 6.55 pIC50 280 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-20528 [PMID:18077363]
ChEMBL Inhibition of SRC B 7.14 pIC50 73 nM IC50 Eur. J. Med. Chem. (2012) 55: 39-48 [PMID:22818848]
GtoPdb - - 7.14 pIC50 73 nM IC50 Eur J Med Chem (2012) 55: 39-48 [PMID:22818848]
YES proto-oncogene 1, Src family tyrosine kinase/Tyrosine-protein kinase YES in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073] [GtoPdb: 2284] [UniProtKB: P07947]
ChEMBL Inhibition of Yes kinase B 7.7 pIC50 20 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-20528 [PMID:18077363]
GtoPdb - - 7.7 pIC50 20 nM IC50 Proc Natl Acad Sci USA (2007) 104: 20523-8 [PMID:18077363]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]