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ChEMBL ligand: CHEMBL473773 (WHI-P154) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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ABCG2/ATP-binding cassette sub-family G member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5393] [GtoPdb: 792] [UniProtKB: Q9UNQ0] | ||||||||
ChEMBL | Inhibition of ABCG2 (unknown origin) expressed in MDCK2 cells co-expressing BCRP (unknown origin) assessed as potentiation of SN-38-induced cytotoxicity measured after 72 hrs by MTT assay | B | 6.72 | pEC50 | 189 | nM | EC50 | Eur J Med Chem (2019) 164: 193-213 [PMID:30594677] |
ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183] | ||||||||
ChEMBL | Inhibition of ABCB1 in human A2780/ADR cells assessed as potentiation of daunorubicin-induced cytotoxicity measured after 72 hrs by MTT assay | B | 5.51 | pEC50 | 3080 | nM | EC50 | Eur J Med Chem (2019) 164: 193-213 [PMID:30594677] |
Janus kinase 1/Tyrosine-protein kinase JAK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2835] [GtoPdb: 2047] [UniProtKB: P23458] | ||||||||
GtoPdb | - | - | 5 | pIC50 | >10000 | nM | IC50 | Blood (2008) 111: 2155-7 [PMID:18094329] |
ChEMBL | Inhibition of JAK1 | B | 5 | pIC50 | >10000 | nM | IC50 | Science (2003) 302: 875-878 [PMID:14593182] |
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674] | ||||||||
GtoPdb | - | - | 5 | pIC50 | >10000 | nM | IC50 | Blood (2008) 111: 2155-7 [PMID:18094329] |
ChEMBL | Inhibition of JAK2 | B | 5 | pIC50 | >10000 | nM | IC50 | Science (2003) 302: 875-878 [PMID:14593182] |
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333] | ||||||||
GtoPdb | - | - | 5.74 | pIC50 | 1800 | nM | IC50 | Blood (2008) 111: 2155-7 [PMID:18094329] |
ChEMBL | Inhibition of JAK3 (unknown origin) | B | 5.74 | pIC50 | 1800 | nM | IC50 | J Med Chem (2018) 61: 9811-9840 [PMID:29969256] |
epidermal growth factor receptor in Human [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
GtoPdb | - | - | 8.4 | pIC50 | 4 | nM | IC50 | Blood (2008) 111: 2155-7 [PMID:18094329] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]