ChEMBL ligand: CHEMBL24777 (Ro-700004, RS-100975)
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348] There should be some charts here, you may need to enable JavaScript!
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368] There should be some charts here, you may need to enable JavaScript!
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100] α1D-adrenoceptor/Alpha-1d adrenergic receptor in Rat [ChEMBL: CHEMBL326] [GtoPdb: 24] [UniProtKB: P23944] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348]
ChEMBL	Binding constant measured against Alpha-1A adrenergic receptor in human prostate; ++:moderately active	B	8.89	pKi	1.3	nM	Ki	Bioorg. Med. Chem. Lett. (2005) 15: 657-664 [PMID:15664832]
ChEMBL	Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1A adrenergic receptor	B	8.9	pKi	1.26	nM	Ki	Bioorg. Med. Chem. Lett. (2003) 13: 1873-1878 [PMID:12749888]
GtoPdb	-	-	8.9	pKi	-	-	-	Br J Pharmacol (1999) 127: 252-8 [PMID:10369480]
ChEMBL	Binding affinity was tested on human Alpha-1A adrenergic receptor	B	9	pKi	1	nM	Ki	J. Med. Chem. (1997) 40: 1293-1315 [PMID:9135028]
ChEMBL	Antagonist inhibition of noradrenaline-stimulated contractions of rabbit bladderneck (RBN) for Alpha-1A adrenergic receptor	F	8.9	pA2	8.9	-	pA2/pKB	Bioorg. Med. Chem. Lett. (2003) 13: 1873-1878 [PMID:12749888]
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368]
GtoPdb	-	-	7.1	pKi	-	-	-	Br J Pharmacol (1999) 127: 252-8 [PMID:10369480]
ChEMBL	Binding affinity was tested on human Alpha-1B adrenergic receptor	B	7.1	pKi	79.43	nM	Ki	J. Med. Chem. (1997) 40: 1293-1315 [PMID:9135028]
ChEMBL	Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1B adrenergic receptor	B	7.1	pKi	79.43	nM	Ki	Bioorg. Med. Chem. Lett. (2003) 13: 1873-1878 [PMID:12749888]
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100]
ChEMBL	Binding affinity was tested on human Alpha-1D adrenergic receptor	B	7	pKi	100	nM	Ki	J. Med. Chem. (1997) 40: 1293-1315 [PMID:9135028]
ChEMBL	Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor	B	7.2	pKi	63.1	nM	Ki	Bioorg. Med. Chem. Lett. (2003) 13: 1873-1878 [PMID:12749888]
GtoPdb	-	-	7.2	pKi	-	-	-	Br J Pharmacol (1999) 127: 252-8 [PMID:10369480]
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL326] [GtoPdb: 24] [UniProtKB: P23944]
ChEMBL	Antagonist inhibition noradrenaline-stimulated contractions of rat aortic strings for Alpha-1D adrenergic receptor	F	6.8	pA2	6.8	-	pA2/pKB	Bioorg. Med. Chem. Lett. (2003) 13: 1873-1878 [PMID:12749888]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]