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ChEMBL ligand: CHEMBL1628648 ([3H]-Nisoxetine) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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NET/Norepinephrine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975] | ||||||||
ChEMBL | Binding affinity to human NET S225H mutant expressed in african green monkey COS1 cells | B | 6.18 | pKd | 656 | nM | Kd | J Biol Chem (2007) 282: 17837-17844 [PMID:17428804] |
ChEMBL | Binding affinity to human NET T381K mutant expressed in african green monkey COS1 cells | B | 6.19 | pKd | 650 | nM | Kd | J Biol Chem (2007) 282: 17837-17844 [PMID:17428804] |
ChEMBL | Binding affinity to human NET F207T mutant expressed in african green monkey COS1 cells | B | 6.5 | pKd | 319 | nM | Kd | J Biol Chem (2007) 282: 17837-17844 [PMID:17428804] |
ChEMBL | Binding affinity to human NET H296S mutant expressed in african green monkey COS1 cells | B | 6.59 | pKd | 257 | nM | Kd | J Biol Chem (2007) 282: 17837-17844 [PMID:17428804] |
ChEMBL | Binding affinity to human NET D473A mutant expressed in african green monkey COS1 cells | B | 7.33 | pKd | 47 | nM | Kd | J Biol Chem (2007) 282: 17837-17844 [PMID:17428804] |
ChEMBL | Binding affinity to human wild type NET expressed in african green monkey COS1 cells | B | 8.29 | pKd | 5.1 | nM | Kd | J Biol Chem (2007) 282: 17837-17844 [PMID:17428804] |
GtoPdb | - | - | 8.4 | pKd | 4 | nM | Kd |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]