NPPB [Ligand Id: 4270] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1256759 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
| ChEMBL | Inhibition of 8-((4-chlorophenyl)amino)naphthalene-1-sulfonic acid binding to CDK2 (unknown origin) measured after 2 hrs by fluorescence based analysis | B | 4.47 | pIC50 | 34000 | nM | IC50 | J Med Chem (2023) 66: 1928-1940 [PMID:36701569] |
| ChEMBL | Inhibition of 8-((4-chlorophenyl)amino)naphthalene-1-sulfonic acid binding to CDK2 (unknown origin) incubated for 2 hrs in presence of staurosporine by fluorescence based analysis | B | 4.8 | pIC50 | 16000 | nM | IC50 | J Med Chem (2023) 66: 1928-1940 [PMID:36701569] |
| histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] | ||||||||
| ChEMBL | Determination of IC50 values for inhibition of enzymatic assay of human HDAC6 with custom peptide substrate | B | 5.55 | pIC50 | 2820 | nM | IC50 | HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators |
| Px1/Pannexin-1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4879520] [GtoPdb: 735] [UniProtKB: Q9JIP4] | ||||||||
| ChEMBL | Inhibition of mouse Panx-1 expressed in Xenopus laevis oocytes assessed as inhibition of membrane current cells held at -60 mV and voltage steps to +60 mV in presence of CBX measured by Whole cell voltage clamp assay relative to control | B | 4.3 | pIC50 | 50000 | nM | IC50 | Eur J Med Chem (2021) 223: 113650-113650 [PMID:34174741] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay | F | 5 | pIC50 | 10000 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762] | ||||||||
| ChEMBL | Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay | B | 6.22 | pEC50 | 602.56 | nM | EC50 | Eur J Med Chem (2019) 170: 141-156 [PMID:30878828] |
| ChEMBL | Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay | B | 6.22 | pEC50 | 600 | nM | EC50 | Eur J Med Chem (2019) 170: 141-156 [PMID:30878828] |
| GtoPdb | FLIPR calcium influx assay | - | 6.49 | pEC50 | - | - | - | Biochem Pharmacol (2010) 80: 113-21 [PMID:20226176] |
| ChEMBL | Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by FLIPR analysis | B | 6.49 | pEC50 | 320 | nM | EC50 | Eur J Med Chem (2019) 170: 141-156 [PMID:30878828] |
| ClC-7 in Human [GtoPdb: 706] [UniProtKB: P51798] | ||||||||
| GtoPdb | - | - | 3.8 | pIC50 | 156000 | nM | IC50 | PLoS ONE (2010) 5: e12585 [PMID:20830208] |
| Maxi Cl- in Human [GtoPdb: 709] | ||||||||
| GtoPdb | - | - | 3.8 | pIC50 | 156000 | nM | IC50 | PLoS ONE (2010) 5: e12585 [PMID:20830208] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
