ChEMBL ligand: CHEMBL279107 (1,4,5-InsP3, Ionositol 1,4,5-Triphosphate)
Inositol 1,4,5-trisphosphate binding protein in Rat [ChEMBL: CHEMBL3364] [UniProtKB: Q62688] There should be some charts here, you may need to enable JavaScript!
IP3R1/Inositol 1,4,5-trisphosphate receptor type 1 in Human [ChEMBL: CHEMBL4046] [GtoPdb: 743] [UniProtKB: Q14643] IP3R1/Inositol 1,4,5-trisphosphate receptor type 1 in Rat [ChEMBL: CHEMBL2804] [GtoPdb: 743] [UniProtKB: P29994] There should be some charts here, you may need to enable JavaScript!
IP3R3/Inositol 1,4,5-trisphosphate receptor type 3 in Human [ChEMBL: CHEMBL3904] [GtoPdb: 745] [UniProtKB: Q14573] Inositol 1,4,5-trisphosphate receptor type 3 in Bovine [ChEMBL: CHEMBL2853] [UniProtKB: Q8WN95] There should be some charts here, you may need to enable JavaScript!
IP3 kinase A/Inositol-trisphosphate 3-kinase A in Rat [ChEMBL: CHEMBL3261] [GtoPdb: 1447] [UniProtKB: P17105] There should be some charts here, you may need to enable JavaScript!
Type 1 InsP3 receptor isoform S2 in Pig [ChEMBL: CHEMBL2950] [UniProtKB: P79248] There should be some charts here, you may need to enable JavaScript!
INPP5A/Type I inositol-1,4,5-trisphosphate 5-phosphatase in Human [ChEMBL: CHEMBL4243] [GtoPdb: 1453] [UniProtKB: Q14642] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Inositol 1,4,5-trisphosphate binding protein in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3364] [UniProtKB: Q62688]
ChEMBL	Compound was tested for inhibition of specific [3H]Ins(1,4,5)P3 binding to Inositol 1,4,5-trisphosphate receptor in rat cerebellar membranes.	B	6.82	pIC50	150	nM	IC50	Bioorg Med Chem Lett (1996) 6: 2197-2200
ChEMBL	Compound was tested for inhibition of specific [3H]Ins(1,4,5)P3 binding to Inositol 1,4,5-trisphosphate receptor in rat cerebellar membranes.	B	7.4	pIC50	40	nM	IC50	Bioorg Med Chem Lett (1996) 6: 2197-2200
IP3R1/Inositol 1,4,5-trisphosphate receptor type 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4046] [GtoPdb: 743] [UniProtKB: Q14643]
ChEMBL	Dissociation constant using IP3-binding domain (IBD) of human Type 1 inositol 1,4,5-trisphosphate receptor	B	6.59	pKd	260	nM	Kd	Bioorg Med Chem Lett (2002) 12: 911-913 [PMID:11958992]
ChEMBL	Binding affinity against Ins(1,4,5)P3 receptor in swiss 3T3 cells	B	6.52	pIC50	300	nM	IC50	Bioorg Med Chem Lett (1995) 5: 1225-1230
IP3R1/Inositol 1,4,5-trisphosphate receptor type 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2804] [GtoPdb: 743] [UniProtKB: P29994]
ChEMBL	Displacement of [3H]-InsP3 from rat type-1 InsP3 receptor expressed in sf9 cell membranes in cytosol like medium containing Mg-ATP	B	6.89	pKd	128.82	nM	Kd	Medchemcomm (2018) 9: 1105-1113 [PMID:30079174]
ChEMBL	Displacement of [3H]-InsP3 from rat type-1 InsP3 receptor expressed in sf9 cell membranes in cytosol like medium containing Mg-ATP	B	6.89	pKd	128	nM	Kd	Medchemcomm (2018) 9: 1105-1113 [PMID:30079174]
ChEMBL	Displacement of [3H]IP3 from full-length rat recombinant IP3R1 expressed in chicken DT40 cells by equilibrium competitive binding assay	B	7.9	pKd	12.5	nM	Kd	Nat Chem Biol (2009) 5: 631-639 [PMID:19668195]
ChEMBL	Displacement of [3H]IP3 from rat IP3R1 expressed in human HEK cells assessed as dissociation constant by radioligand binding assay	B	8.06	pKd	8.71	nM	Kd	J Med Chem (2020) 63: 3238-3251 [PMID:32052631]
ChEMBL	Displacement of [3H]IP3 from rat IP3R1 expressed in human HEK cells assessed as dissociation constant by radioligand binding assay	B	8.06	pKd	8.71	nM	Kd	J Med Chem (2020) 63: 3238-3251 [PMID:32052631]
ChEMBL	Displacement of [3H]-IP3 from IP3R1 in Wistar rat cerebellar membrane measured after 5 mins by liquid scintillation counting method	B	8.06	pKd	8.7	nM	Kd	J Med Chem (2020) 63: 5442-5457 [PMID:32286062]
ChEMBL	Displacement of [3H]IP3 from rat recombinant IP3R1 N-terminal residue (1-604) K52E mutant expressed in chicken DT40 cells by equilibrium competitive binding assay	B	8.58	pKd	2.64	nM	Kd	Nat Chem Biol (2009) 5: 631-639 [PMID:19668195]
ChEMBL	Displacement of [3H]IP3 from rat recombinant N-terminal IP3R1 (1-604) expressed in chicken DT40 cells by equilibrium competitive binding assay	B	8.63	pKd	2.32	nM	Kd	Nat Chem Biol (2009) 5: 631-639 [PMID:19668195]
ChEMBL	Displacement of [3H]IP3 from rat recombinant IP3R1 N-terminal residue (1-604) D34K mutant expressed in chicken DT40 cells by equilibrium competitive binding assay	B	9.01	pKd	0.98	nM	Kd	Nat Chem Biol (2009) 5: 631-639 [PMID:19668195]
ChEMBL	Displacement of [3H]IP3 from rat recombinant IP3R1 N-terminal residue (1-604) R36E mutant expressed in chicken DT40 cells by equilibrium competitive binding assay	B	9.34	pKd	0.46	nM	Kd	Nat Chem Biol (2009) 5: 631-639 [PMID:19668195]
ChEMBL	Displacement of [3H]IP3 from rat recombinant IP3R1 N-terminal residue (1-604) K127E mutant expressed in chicken DT40 cells by equilibrium competitive binding assay	B	9.35	pKd	0.45	nM	Kd	Nat Chem Biol (2009) 5: 631-639 [PMID:19668195]
ChEMBL	Displacement of [3H]IP3 from rat recombinant IP3R1 N-terminal residue (1-604) V33K mutant expressed in chicken DT40 cells by equilibrium competitive binding assay	B	9.57	pKd	0.27	nM	Kd	Nat Chem Biol (2009) 5: 631-639 [PMID:19668195]
ChEMBL	Displacement of [3H]IP3 from rat recombinant IP3R1 binding core residue (224-604) expressed in chicken DT40 cells by equilibrium competitive binding assay	B	9.68	pKd	0.21	nM	Kd	Nat Chem Biol (2009) 5: 631-639 [PMID:19668195]
ChEMBL	Agonist activity at rat IP3R1 expressed in human HEK cells assessed as increase in calcium release by Mag-fluo4 dye based assay	B	6.68	pEC50	209	nM	EC50	J Med Chem (2020) 63: 3238-3251 [PMID:32052631]
ChEMBL	Agonist activity at rat IP3R1 expressed in human HEK cells assessed as increase in calcium release by Mag-fluo4 dye based assay	B	6.68	pEC50	208.93	nM	EC50	J Med Chem (2020) 63: 3238-3251 [PMID:32052631]
ChEMBL	Agonist activity at rat IP3R1 expressed in DT40 cells assessed as increase in calcium release by Mag-fluo4 dye based assay	B	6.88	pEC50	133	nM	EC50	J Med Chem (2020) 63: 3238-3251 [PMID:32052631]
ChEMBL	Agonist activity at rat IP3R1 expressed in DT40 cells assessed as increase in calcium release by Mag-fluo4 dye based assay	B	6.88	pEC50	131.83	nM	EC50	J Med Chem (2020) 63: 3238-3251 [PMID:32052631]
ChEMBL	Agonist activity at rat IP3R1 expressed in HEK cells assessed as increase in calcium release in cytosol by measuring fluorescence signal by Mag-Fluo4 dye based assay	B	6.9	pEC50	126	nM	EC50	J Med Chem (2020) 63: 5442-5457 [PMID:32286062]
ChEMBL	Agonist activity at rat IP3R1 expressed in HEK cells assessed as increase in calcium release in cytosol by measuring fluorescence signal by Mag-Fluo4 dye based assay	B	6.9	pEC50	125.89	nM	EC50	J Med Chem (2020) 63: 5442-5457 [PMID:32286062]
ChEMBL	Agonist activity at rat recombinant IP3R1 K52E mutant expressed in chicken DT40 cells assessed as calcium release from intracellular stores	F	7.07	pEC50	85	nM	EC50	Nat Chem Biol (2009) 5: 631-639 [PMID:19668195]
ChEMBL	Agonist activity at rat type-1 InsP3 receptor expressed in chicken DT40 cells in cytosol like medium assessed as increase in calcium release by fluorescence assay	B	7.21	pEC50	62	nM	EC50	Medchemcomm (2018) 9: 1105-1113 [PMID:30079174]
ChEMBL	Agonist activity at rat type-1 InsP3 receptor expressed in chicken DT40 cells in cytosol like medium assessed as increase in calcium release by fluorescence assay	B	7.21	pEC50	61.66	nM	EC50	Medchemcomm (2018) 9: 1105-1113 [PMID:30079174]
ChEMBL	Agonist activity at rat recombinant IP3R1 R36E mutant expressed in chicken DT40 cells assessed as calcium release from intracellular stores	F	7.39	pEC50	40.8	nM	EC50	Nat Chem Biol (2009) 5: 631-639 [PMID:19668195]
ChEMBL	Agonist activity at rat recombinant IP3R1 D34K mutant expressed in chicken DT40 cells assessed as calcium release from intracellular stores	F	7.58	pEC50	26.6	nM	EC50	Nat Chem Biol (2009) 5: 631-639 [PMID:19668195]
ChEMBL	Agonistic potency at rat IP3 type 1 receptor expressed in chicken DT40 cells	F	7.61	pEC50	24.8	nM	EC50	J Med Chem (2006) 49: 1900-1909 [PMID:16539376]
ChEMBL	Activity at rat IP3 type 1 receptor expressed in DT40 cell assessed as calcium ion mobilization	F	7.61	pEC50	24.8	nM	EC50	J Med Chem (2006) 49: 5750-5758 [PMID:16970399]
ChEMBL	Agonist activity at rat IP3R1 expressed in chicken DT40 cells assessed as induction of Ca2+ release	F	7.64	pEC50	23	nM	EC50	J Med Chem (2012) 55: 1706-1720 [PMID:22248345]
ChEMBL	Agonist activity at rat recombinant IP3R1 V33K mutant expressed in chicken DT40 cells assessed as calcium release from intracellular stores	F	7.65	pEC50	22.3	nM	EC50	Nat Chem Biol (2009) 5: 631-639 [PMID:19668195]
ChEMBL	Agonist activity at rat recombinant IP3R1 expressed in chicken DT40 cells assessed as calcium release from intracellular stores	F	7.7	pEC50	20	nM	EC50	Nat Chem Biol (2009) 5: 631-639 [PMID:19668195]
IP3R3/Inositol 1,4,5-trisphosphate receptor type 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3904] [GtoPdb: 745] [UniProtKB: Q14573]
ChEMBL	Dissociation constant of compound was measured in IP3-binding domain(IBD) of human Inositol 1,4,5-trisphosphate receptor at pH 7.4	B	6.71	pKd	195	nM	Kd	Bioorg Med Chem Lett (1999) 9: 1697-1702 [PMID:10397504]
Inositol 1,4,5-trisphosphate receptor type 3 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2853] [UniProtKB: Q8WN95]
ChEMBL	Binding affinity against Inositol 1,4,5-trisphosphate receptor on bovine adrenal cortex microsomes.	B	4.85	pIC50	14000	nM	IC50	J Med Chem (1999) 42: 4824-4835 [PMID:10579845]
IP3 kinase A/Inositol-trisphosphate 3-kinase A in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3261] [GtoPdb: 1447] [UniProtKB: P17105]
ChEMBL	Binding affinity against recombinant plasmid rat brain IP3K by overexpressing in Escherichia coli	B	4.36	pIC50	43700	nM	IC50	Bioorg Med Chem Lett (2003) 13: 2981-2984 [PMID:12941316]
ChEMBL	Binding affinity against recombinant plasmid rat brain IP3K by overexpressing in Escherichia coli	B	5.2	pIC50	6300	nM	IC50	Bioorg Med Chem Lett (2003) 13: 2981-2984 [PMID:12941316]
ChEMBL	Binding affinity against recombinant plasmid rat brain IP3K by overexpressing in Escherichia coli	B	5.59	pIC50	2600	nM	IC50	Bioorg Med Chem Lett (2003) 13: 2981-2984 [PMID:12941316]
Type 1 InsP3 receptor isoform S2 in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2950] [UniProtKB: P79248]
ChEMBL	Binding affinity of compound was determined by its ability to displace specifically bound Inositol 1,4,5-trisphosphate receptor from purified porcine cerebellum membrane	B	7.7	pIC50	20	nM	IC50	Bioorg Med Chem Lett (1995) 5: 831-834
INPP5A/Type I inositol-1,4,5-trisphosphate 5-phosphatase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4243] [GtoPdb: 1453] [UniProtKB: Q14642]
ChEMBL	Tested for inhibition of 5-phosphatase isolated from human erythrocyte membrane (S substrate)	B	4.82	pKi	15000	nM	Ki	J Med Chem (1993) 36: 3035-3038 [PMID:8411022]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]