conantokin-G [Ligand Id: 4161] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL525025 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| GluN2A/Glutamate receptor ionotropic, NMDA 2A in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL310] [GtoPdb: 456] [UniProtKB: Q00959] | ||||||||
| ChEMBL | Inhibition of rat NMDA NR2A receptor expressed in xenopus oocytes coexpressing NMDA NR13b assessed as effect on glycine-induced current response at -70 mV by voltage clamp method | B | 5 | pIC50 | >10000 | nM | IC50 | J Biol Chem (2007) 282: 36905-36913 [PMID:17962189] |
| GluN2B/Glutamate receptor ionotropic, NMDA 2B in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL311] [GtoPdb: 457] [UniProtKB: Q00960] | ||||||||
| ChEMBL | Inhibition of rat NMDA NR2B receptor expressed in xenopus oocytes coexpressing NMDA NR13b assessed as effect on glycine-induced current response at -70 mV by voltage clamp method | B | 7 | pIC50 | 100 | nM | IC50 | J Biol Chem (2007) 282: 36905-36913 [PMID:17962189] |
| GluN2C/Glutamate receptor ionotropic, NMDA 2C in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL401] [GtoPdb: 458] [UniProtKB: Q00961] | ||||||||
| ChEMBL | Inhibition of rat NMDA NR2C receptor expressed in xenopus oocytes coexpressing NMDA NR13b assessed as effect on glycine-induced current response at -70 mV by voltage clamp method | B | 6 | pIC50 | 1000 | nM | IC50 | J Biol Chem (2007) 282: 36905-36913 [PMID:17962189] |
| GluN2D/Glutamate receptor ionotropic, NMDA 2D in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL303] [GtoPdb: 459] [UniProtKB: Q62645] | ||||||||
| ChEMBL | Inhibition of rat NMDA NR2D receptor expressed in xenopus oocytes coexpressing NMDA NR13b assessed as effect on glycine-induced current response at -70 mV by voltage clamp method | B | 6 | pIC50 | 1000 | nM | IC50 | J Biol Chem (2007) 282: 36905-36913 [PMID:17962189] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
