retinol [Ligand Id: 4053] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL986 (Aquasol a, Arovit, Nepalm, NSC-122759, Oleovitamin a, Retinol, Retinol acetate, Retinol palmitate, Retinol (vit a), Ro-a-vit, Vitamin a, Vitamin A, Vitamin A 1, Vitamin a oil, Vitamin A Solubilized)
Created with Highcharts 10.3.3ValuesChart context menuAlpha-synucleinpKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuAmyloid-beta A4 proteinpKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuBeta-lactoglobulinpKd BovinepKi BovinepIC50 BovinepEC50 Bovine02468Highcharts.com
  • retinol binding protein 4/Plasma retinol-binding protein in Human [ChEMBL: CHEMBL3100] [GtoPdb: 2549] [UniProtKB: P02753]
Created with Highcharts 10.3.3ValuesChart context menuPlasma retinol-binding proteinpKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • Testicular receptor 4 in Human [GtoPdb: 614] [UniProtKB: P49116]
Created with Highcharts 10.3.3ValuesChart context menuTesticular receptor 4pKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
synuclein alpha/Alpha-synuclein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6152] [GtoPdb: 3285] [UniProtKB: P37840]
ChEMBL Inhibition of alpha-synuclein fibril formation (unknown origin) incubated for 24 hrs to 7 days by thioflavin S based fluorescence assay B 6.72 pIC50 190 nM IC50 Eur J Med Chem (2019) 167: 10-36 [PMID:30743095]
Amyloid-beta A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067]
ChEMBL Inhibition of amyloid beta (1 to 40) (unknown origin) incubated for 24 hrs to 7 days by thioflavin S based fluorescence assay B 6.74 pIC50 180 nM IC50 Eur J Med Chem (2019) 167: 10-36 [PMID:30743095]
Beta-lactoglobulin in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075053] [UniProtKB: P02754]
ChEMBL Binding affinity to bovine beta-lactoglobulins by fluorescence spectroscopy B 7.44 pKd 36 nM Kd J Med Chem (2010) 53: 514-518 [PMID:19938842]
retinol binding protein 4/Plasma retinol-binding protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3100] [GtoPdb: 2549] [UniProtKB: P02753]
ChEMBL Binding affinity to His-tagged recombinant human sRBP expressed in Escherichia coli BL21(DE3) assessed as apparent dissociation constant after 5 mins by fluorescence spectrophotometric analysis B 6.74 pKd 182 nM Kd J Med Chem (2011) 54: 4378-4387 [PMID:21591606]
Testicular receptor 4 in Human [GtoPdb: 614] [UniProtKB: P49116]
GtoPdb - - 4.71 pEC50 19400 nM EC50 J Biol Chem (2011) 286: 2877-85 [PMID:21068381]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]